重庆市某农村地区5~6岁儿童尿液中邻苯二甲酸酯类代谢物调查  

Urinary phthalate metabolites in children aged 5-6 years in some rural areas of Chongqing

作　　者：雷春萍[1] 郑代坤[2] 牟伦武 程永宏 谭中乐 代兴碧[4] 钟慧云 LEI Chun-ping;ZHENG Dai-kun;MOU Lun-wu;CHENG Yong-hong;TAN Zhong-le;DAI Xing-bi;ZHONG Hui-yun(Department of Public Health and Management in Chongqing Three Gorges Medical College,Chongqing 404120,China;不详)

机构地区：[1]重庆三峡医药高等专科学校公共卫生与管理学院,重庆404120 [2]万州区疾病预防控制中心 [3]万州区长滩卫生院 [4]重庆医科大学院公共卫生与管理学院 [5]重庆市九龙坡社区卫生服务中心

出　　处：《环境与健康杂志》2019年第6期520-522,共3页Journal of Environment and Health

基　　金：重庆市教委科学技术研究项目(KJ1402505).

摘　　要：目的了解重庆市某农村地区5~6岁年龄组儿童邻苯二甲酸酯的暴露水平。方法于2010年3-6月,通过分层整群随机抽样方法,随机抽取了重庆市某县6个乡镇中心幼儿园的210名5~6岁儿童(其中,男性108人,女性102人),检测随机尿液中邻苯二甲酸酯(PAEs)五种一级代谢产物[邻苯二甲酸单甲酯(MMP)、邻苯二甲酸单丁酯(MBP)、邻苯二甲酸单乙酯(MEP)、邻苯二甲酸单苄基酯(MBzP)和邻苯二甲酸单(2-乙基己基)酯(MEHP)]的浓度。结果除MBzP未检出外,尿中其余4种PAEs代谢产物的检出率依次为MEHP(84.76%)>MBP(73.81%)>MMP(6.67%)>MEP(4.76%)。不同性别儿童尿中MMP、MEP、MBP、MEHP的浓度和检出率间比较,差异均无统计学意义(P>0.05)。结论该地区5~6岁儿童受MBP和MEHP原型物邻苯二甲酸二甲酯(DBP)和邻苯二甲酸二(2-乙基己基)酯(DEHP)的污染较为严重。Objective To understand the exposure levels of phthalate metabolites among children aged 5-6 years in some rural areas of Chongqing. Methods A total of 210 participants(108 boys and 102 girls,aged 5-6) from six township center kindergartens were recruited by stratified cluster sampling in a county of Chongqing from March to June in 2010. Five phthalate metabolites including monomethyl phthalate(MMP),mono-n-butyl phthalate(MBP),monoethyl phthalate(MEP),monobenzyl phthalate(MBzP) and mono(2-ethylhexyl)phthalate(MEHP) in spot urine samples were analyzed. Results The detection rates of MEHP,MBP,MMP,MEP and MBzP were ranked as 84.76%,73.81%,6.67%,4.76% and 0.00%. The levels and detection rates of MMP,MEP,MBP and MEHP in urine had no significant differences between boys and girls(P>0.05).Conclusion The exposure levels of dimethyl phthalate(DBP) and diethyl hexyl phthalate(DEHP),the prototypes of MBP and MEHP,are higher in the children aged 5-6 years in the investigated areas.

关 键 词：邻苯二甲酸酯 代谢产物 尿 儿童 农村 

分 类 号：R181.3[医药卫生—流行病学]