维生素D与儿童支气管哮喘  

Vitamin D and childhood asthma

作　　者：陈雪 陈蒙[1] CHEN Xue;CHEN Meng(Department of Respiration,the Affiliated Children’s Hospital of Nanjing Medical University,Nanjing 210008,China)

机构地区：[1]南京医科大学附属儿童医院呼吸科,江苏南京210008

出　　处：《南京医科大学学报（自然科学版）》2020年第3期454-460,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：南京市医学科技发展项目(YKK161980)。

摘　　要：维生素D对钙吸收及骨代谢起重要作用。越来越多的研究发现,维生素D还参与多种感染、炎症及免疫反应的调节过程。维生素D还对多种细胞有重要的调节作用。维生素D不足和缺乏在世界范围内均很普遍,在支气管哮喘儿童中这一现象更加显著。支气管哮喘的病理生理学表现为慢性炎症、气道高反应性和气道重塑。维生素D可能影响哮喘的发生、发展过程。文章阐述了维生素D与哮喘发病率的相关性、维生素D影响哮喘的发病机制及维生素D辅助治疗儿童支气管哮喘的疗效。Vitamin D plays an important role in calcium absorption and bone metabolism.More and more studies have found that vitamin D is also involved in the modulation of infection,inflammatory and immune responses.Vitamin D also plays an important role in regulating a variety of cells.Vitamin D insufficiency and deficiency are common worldwide,which is more common in children with bronchial asthma.The pathophysiology of bronchial asthma is chronic inflammation,airway hyperresponsiveness and airway remodeling.Vitamin D may affect the occurrence and development process of asthma.This review summarized the correlation between vitamin D and the morbidity of asthma,the mechanisms of vitamin D affecting asthma,and the clinical effects of vitamin D as an adjuvant therapy for childhood asthma.

关 键 词：儿童 支气管哮喘 维生素D 免疫机制 T细胞 

分 类 号：R725.6[医药卫生—儿科]