生长激素在体外受精助孕中的应用进展  

Application of growth hormone in in vitro fertilization assisted pregnancy

作　　者：李月 康晓敏 武泽[2] Li Yue;Kang Xiaomin;Wu Ze(Department of Obstetrics and Gynecology,Dali University,Dali 671000,China;Department of Reproductive Medicine,the First People's Hospital of Yunnan Province,Kunming 650032,China)

机构地区：[1]大理大学妇产科学,671000 [2]云南省第一人民医院生殖医学科,昆明650032

出　　处：《中华生殖与避孕杂志》2020年第2期129-133,共5页Chinese Journal of Reproduction and Contraception

摘　　要：目前越来越多的不孕女性需要借助辅助生殖技术完成妊娠,然而在体外受精-胚胎移植(IVF-ET)过程中一部分患者常常由于卵巢反应性差、卵泡发育不良和子宫内膜容受性差导致妊娠成功率降低。提高患者卵巢反应性、卵母细胞质量和子宫内膜容受性以改善IVF-ET结局成为了广大临床及实验室工作者共同面对的挑战,这成为辅助生殖领域的一大难题。生长激素主要作用是促进全身组织器官生长,尤其是骨骼与肌肉组织,还能调节体内三大物质的代谢,促进蛋白质合成,抑制脂肪代谢,升高血糖等。研究显示生长激素在女性生殖健康中也发挥了巨大作用,主要表现在增加卵巢对促性腺激素的反应性,优化卵泡及卵子质量,提高胚胎质量,增加子宫内膜厚度从而提高子宫内膜容受性等。本篇综述就生长激素对女性生殖系统的作用、适用人群及用法展开论述。At present,more and more infertile women need to use assisted reproductive technology to complete pregnancy.However,in the in vitro fertilization and embryo transfer(IVF-ET)process,some patients often have lower pregnancy success rate due to poor ovarian reactivity,poor follicular dysplasia and poor endometrial receptivity.Increased ovarian responsiveness,oocyte quality and endometrial receptivity to improve IVF-ET outcomes has become a common challenge for clinical and laboratory workers,which has become a major problem in the field of assisted reproduction.The main role of growth hormone is promoting the growth of whole body tissues and organs,especially bones and muscles.It can also regulate the metabolism of three major substances in the body,promote protein synthesis,inhibit fat metabolism,raise blood sugar,etc.At this stage,growth hormone also plays a huge role in female reproductive health,mainly in increasing the ovarian response to gonadotropins,optimizing follicle oocyte quality,improving embryo quality,increasing endometrial thickness and improving endometrial receptivity.This review focuses on the role of growth hormone in the female reproductive system,the applicable population and usage.

关 键 词：生长激素 卵巢反应性 卵母细胞质量 子宫内膜容受性 适用人群 用法 

分 类 号：R714[医药卫生—妇产科学]