人胎盘间充质干细胞修复卵巢早衰小鼠卵巢功能的作用和分子机制研究进展  

Role and molecular mechanisms of human placenta-derived mesenchymal stem cells in the restoration of ovary function in premature ovarian failure mice

作　　者：刘梦 朱怡卿 印惠荣 王芳 Liu Meng;Zhu Yiqing;Yin Huirong;Wang Fang(Department of Medical Genetics,College of Basic Medical Sciences,Naval Military Medical University,Shanghai 200433,China;Reproductive Medicine Center,the Affiliated Changhai Hospital of Naval Military Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学医学遗传学教研室,上海200433 [2]海军军医大学附属长海医院生殖医学中心,上海200433

出　　处：《中华生殖与避孕杂志》2020年第2期166-169,共4页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金(81672775)。

摘　　要：近年来,人们对间充质干细胞(mesenchymal stem cells,MSCs)修复损伤组织的研究给予了更多关注,也越来越多地考虑用各种不同来源的MSCs治疗卵巢早衰(premature ovarian failure,POF)/早发性卵巢功能不全(premature ovarian insufficiency,POI)。人胎盘间充质干细胞(hPMSCs)具有多向分化和保护内皮细胞免受损伤的能力,是用于组织修复的种子细胞。相关研究表明hPMSCs移植对动物POF的治疗有一定的积极作用,但hPMSCs并未广泛应用于临床治疗,临床试验仍在进行中。本文讨论了hPMSCs治疗POF的可能机制,涉及抗炎和免疫调节、促进卵泡发育和血管生成、抗颗粒细胞凋亡、氧化应激,可为进一步研究和临床治疗提供理论依据。In recent years,more attention has been paid to the contributions of mesenchymal stem cells(MSCs)to tissue repair.Various MSCs are increasingly considered for the treatment of premature ovarian failure(POF)/premature ovarian insufficiency(POI).Human placenta-derived mesenchymal stem cells(hPMSCs)have become seed cells for tissue repair due to their multilineage differentiation potential and ability of protecting endothelial cells from damage.Related researches have demonstrated that hPMSCs transplantation has a certain positive effect on the treatment of POF animal,but hPMSCs are not widely used in clinical treatment,clinical trials are still in progress.We reviewed the possible mechanisms by which hPMSCs ameliorate POF,anti-inflammatory effects and immunoregulatory effects,folliculogenesis,angiogenesis,antiapoptotic effects,and oxidative stress effects,providing a theoretical basis for further research and clinical treatment.

关 键 词：间充质干细胞 胎盘 自身免疫 早发性卵巢功能不全 卵巢早衰 

分 类 号：R711[医药卫生—妇产科学]