双膦配体拆分2-氯扁桃酸对映体性能研究  

Enantioseparation of 2-chloromandelic acid enantiomers using chiral diphosphine ligands as extractants

作　　者：刘雄 马雨 周文琦 肖文洁 王俊 LIU Xiong;MA Yu;ZHOU Wen-qi;XIAO Wen-jie;WANG Jun(School of Chemistry and Chemical Engineering,Hunan University of Science and Technology,Xiangtan 411201,Hunan Province,China)

机构地区：[1]湖南科技大学化学化工学院,湖南湘潭411201

出　　处：《化学工程》2020年第3期26-31,67,共7页Chemical Engineering(China)

基　　金：国家自然科学基金资助项目(51703060);湖南省研究生科研创新项目(CX2018B673)。

摘　　要：以轴手性双膦配体(S)-BINAP、(S)-SEGPHOS和(S)-MeO-BIPHEP为手性萃取剂对2-氯扁桃酸对映体进行了拆分,采用响应曲面法系统考察了萃取剂浓度、水相pH值和萃取温度对2-氯扁桃酸拆分性能的影响。实验结果表明:(S)-SEGPHOS-Cu对2-氯扁桃酸对映体具有良好的识别能力;最佳萃取条件为萃取剂浓度为2.8 mmol/L,pH 7.8,温度5.0℃;在最优条件下,萃取性能因子pf的预测和实验值分别为0.313和0.307。Chiral diphosphine ligands,such as(S)-BINAP,(S)-SEGPHOS and(S)-MeO-BIPHEP,were used as chiral extractants to separate 2-chloromandelic acid enantiomers.The influences of extractant concentration,pH and extraction temperature on extractions were investigated.The results show that(S)-SEGPHOS-Cu has considerable ability to recognize 2-chloromandelic acid enantiomers.After optimized by response surface method,the optimal extraction condition is(S)-SEGPHOS-Cu concentration of 2.8 mmol/L,pH of 7.8,extraction temperature of 5.0℃.The predicted and experimental performance factors(p f)are 0.313 and 0.307,respectively.

关 键 词：轴手性双膦配体 液-液手性萃取 2-氯扁桃酸 响应曲面法 

分 类 号：TQ028.4[化学工程]