气态污染物与上海市浦东新区居民心脑血管疾病死亡相关性的病例交叉研究  

A case一crossover study on relationship between gaseous pollutant and mortality of cardio-cerebrovascular disease,Pudong New Area,Shanghai

作　　者：陈亦晨 孙良红[1,2] 李小攀 陈华[1,2] 陈涵一 张格[1,2] 曲晓滨 周弋[1,2] 肖绍坦 CHEN Yi-chen;SUN Liang-hong;LI Xiao-pan;CHEN Hua;CHEN Han-yi;ZHANG Ge;QU Xiao-bin;ZHOU Yi;XIAO Shao-tan(Shanghai Pudong New Area Center for Disease Control and Prevention,Shanghai 200136,China)

机构地区：[1]上海市浦东新区疾病预防控制中心,上海200136 [2]复旦大学浦东预防医学研究院,上海200136

出　　处：《现代预防医学》2020年第7期1187-1191,共5页Modern Preventive Medicine

基　　金：上海市浦东新区卫生系统重点学科建设(PWZxk2017-28);上海市浦东新区卫生系统优秀青年医学人才培养计划(PWRq2017-33);浦东新区疾病预防控制中心卫生科技项目(PDCDC-2018-06)。

摘　　要：目的评估气态污染物与浦东新区居民每日心脑血管疾病死亡的关联性,为制定相应的干预措施提供依据。方法收集浦东新区2005年1月1日-2017年12年31日的气象因素、大气污染及居民心脑血管疾病死亡资料,采用时间分层-病例交叉研究的方法,评估气态污染物对浦东新区居民心脑血管疾病死亡的影响。结果研究期间,上海市SO2与NO2的平均浓度分别为31.96μg/m^3和45.21μg/m^3。SO2与NO2与浦东新区居民心脑血管疾病死亡存在相关性。SO2与NO2的效应分别在滞后3 d(lag3)与当日(lag0)强度最大,SO2浓度每上升10μg/m^3,在滞后3d(lag3)时居民每日心脑血管疾病死亡将上升1.12%(95%CI:0.69%~1.56%);NO2浓度每上升10μg/m^3,在当日居民每日心脑血管疾病死亡将上升0.85%(95%CI:0.40%~1.30%)。多污染物模型中,在控制了PM(10)与NO2的影响后,SO2的效应保持稳定,在控制了PM(10)与SO2的影响后,NO2的效应有所加强。结论 SO2与NO2浓度与每日浦东新区居民心脑血管疾病死亡存在相关性,其中SO2的效应在滞后3 d影响最大,NO2在当日影响最大。Objective To explore the relationship between the concentration of gaseous pollutant including SO2 and NO2 with daily mortality of cardio-cerebrovascular disease in Pudong New Area,so as to provide a reference for the establishment of the intervention measures.Methods The data including meteorology,air pollution and daily death of cardio-cerebrovascular disease in Pudong New Area from January 1,2005 to December 31,2017 were collected and a time stratified case-crossover study was conducted to assess the relationship between air gaseous pollutants(SO2 and NO2)and daily mortality of cardio-cerebrovascular disease.Results The daily average concentrations of SO2 and NO2 were 31.96μg/m^3 and 45.21μg/m^3,respectively.The strongest effects were observed on three days lag of SO2 and the same day of NO2.When the daily average concentrations of SO2 increased by 10μg/m^3,the corresponding increase of daily mortality of cardio-cerebral vascular disease was 1.12%(95%CI:0.69%-1.56%)at lag3.When the daily average concentrations of NO2 increased by 10μg/m^3,the corresponding increase of daily cardio-cerebral vascular disease mortality was 0.85%(95%CI:0.40%-1.30%)at lag0.Multi-pollutant analysis suggested that the effect of SO2 kept stable after adjustment for NO2 and PM10,and the effect of NO2 was stronger after adjustment for SO2 and PM10.Conclusion The increase on the concentration of SO2 and NO2 has adverse effect on daily mortality of cardio-cerebrovascular disease of local residents in Pudong New Area.The effects of SO2 and NO2 are strongest on three days lag and the same day,respectively.

关 键 词：气态污染物 死亡 心脑血管疾病 时间分层-病例交叉研究 

分 类 号：R181.3[医药卫生—流行病学] R54[医药卫生—公共卫生与预防医学]