银催化2-芳基吲哚与马来酰亚胺C—H键烷基化反应  

Silver-Catalyzed C—H Alkylation of 2-Arylindoles with Maleimides

作　　者：皮超[1] 曲亚平 崔秀灵[1] 吴养洁[1] Pi Chao;Qu Yaping;Cui Xiuling;Wu Yangjie(Henan Key Laboratory of Chemical Biology and Organic Chemistry,Key Laboratory of Applied Chemistry of Henan Universities,College of Chemistry,Zhengzhou University,Zhengzhou 450052)

机构地区：[1]郑州大学化学学院河南省化学生物与有机化学重点实验室河南省高等学校应用化学重点开放实验室,郑州450052

出　　处：《有机化学》2020年第3期740-747,共8页Chinese Journal of Organic Chemistry

基　　金：科技部国际合作重点专项(No.2016YFE0132600)资助项目.

摘　　要：发展了一种银催化高效高区域选择性的2-芳基吲哚C-3位烷基化反应.在温和条件下,能以高达97%的收率得到目标化合物,且该方法操作简单,不需要外加氧化剂.A highly efficient and regioselective C-3-alkylation of 2-arylindoles with maleimides has been developed using Ag(Ⅰ)as catalyst.3-(2-Aryl-1H-indol-3-yl)pyrrolidine-2,5-diones were afforded with high yields(up to 97%)under relatively mild reaction conditions.The method features operational simplicity and avoiding external oxidant.

关 键 词：银催化 2-芳基吲哚 马来酰亚胺 烷基化 

分 类 号：O621.251[理学—有机化学]