氰基亚胺与亚甲基二氢苯并呋喃二酮类化合物的[3+2]环加成反应:螺吡唑类化合物的合成  

[3+2]Cycloaddition of Methylenedihydrobenzofurandiones and Nitrilimines:Synthesis of Sipropyrazole Compounds

作　　者：史望宇 徐嘉擎 毛比明 贾皓 黄家兴 郭红超[1] Shi Wangyu;Xu Jiaqing;Mao Biming;Jia Hao;Huang Jiaxing;Guo Hongchao(Department of Chemistry,College of Science China Agricultural University Beijing 100193)

机构地区：[1]中国农业大学理学院化学系,北京100193

出　　处：《有机化学》2020年第3期756-762,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21572264)资助项目.

摘　　要：采用具有环外双键的二氢苯并呋喃二酮类化合物和氰基亚胺的[3+2]环加成反应,在温和条件下,以高产率(78%~94%)和高非对映选择性(>20∶1dr)构建了一系列具有螺环结构的吡唑类化合物.The[3+2]cycloaddition of methylenedihydrobenzofbrandiones and nitrilimines worked efficiently in CHC13 at room temperature in the presence of Et3N,producing biologically interesting spirocyclic pyrazole derivatives in high yield(78%?94%)with excellent diastereoselectivity.

关 键 词：环加成 氰基亚胺 螺环化合物 吡唑 

分 类 号：O626[理学—有机化学] O621.3[理学—化学]