基于栝楼不同药用部位化学成分和性效关系的质量标志物分析  

Analysis of quality markers based on efficacy and material base of different medicinal parts of Trichosanthes kirilowii

作　　者：唐昀彤 杜正彩 郝二伟[2,3,4] 谢金玲 侯小涛[1,2,3] 邓家刚 TANG Yun-tong;DU Zheng-cai;HAO Er-wei;XIE Jin-ling;HOU Xiao-tao;DENG Jia-gang(School of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China;Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica,Nanning 530200,China;Guangxi Collaborative Innovation Center of Functional Ingredients of Agricultural Residues,Nanning 530200,China;Guangxi Scientific Experimental Center of Traditional Chinese Medicine,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学药学院,广西南宁530200 [2]广西中药药效研究重点实验室,广西南宁530200 [3]广西农作物废弃物功能成分研究协同创新中心,广西南宁530200 [4]广西中医药大学广西中医药科学实验中心,广西南宁530200

出　　处：《中草药》2020年第6期1617-1627,共11页Chinese Traditional and Herbal Drugs

基　　金：广西科技计划基地和人才专项重点实验室建设项目(广西中药药效研究重点实验室17-259-20);农作物废弃物功能成分研究协同创新中心建设项目(CICAR2017-Z1);广西科学研究与技术开发计划项目(桂科AD17195025)。

摘　　要：栝楼的不同部位皆可入药,分别为瓜蒌(果实)、瓜蒌皮(果皮)、瓜蒌子(种子)和天花粉(根)。现代研究证实,栝楼皮主要有效成分为黄酮类、氨基酸等;栝楼籽主要含有萜类、甾醇类等成分;天花粉主要含蛋白质、萜类、多糖等成分。且各个药用部位的药理作用也存在差异。对栝楼的不同药用部位的传统功效、化学成分和药理作用进行总结,分析各部位化学成分与传统应用、现代药理作用之间的关系,并基于此对栝楼的质量标志物进行分析和预测。Different parts of Trichosanthes kirilowii can all be used as medicines, including the fruits(Trichosanthis Fructus), pericarps(Trichosanthis Pericarpium), seeds(Trichosanthis Semen) and roots(Trichosanthis Radix). Modern research has confirmed that the main active ingredients of Trichosanthis Pericarpium are flavonoids and amino acids;Trichosanthis Semen mainly contains terpenoids and sterols;Trichosanthis Radix mainly contains protein, steroids and polysaccharides. And the pharmacological effects of various medicinal parts are also different. This paper summarizes the traditional efficacy, chemical composition and modern pharmacological effects of different medicinal parts of T. kirilowii, analyzes the relationship between them, so as to analyze and predict the quality marker of T. kirilowii.

关 键 词：栝楼 双边栝楼 瓜蒌 天花粉 瓜蒌皮 瓜蒌子 质量标志物 天花粉凝集素 天花粉蛋白 葫芦素B 

分 类 号：R282.71[医药卫生—中药学]