大孔树脂分离富集生物碱类成分研究进展  

Research progress on macroporous resin application in enriching and separating alkaloids

作　　者：刘岩 陈伟豪 亢迪 李文龙 李正 LIU Yan;CHEN Wei-hao;KANG Di;LI Wen-long;LI Zheng(College of Pharmaceutical Engineering of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学中药制药工程学院,天津301617

出　　处：《中草药》2020年第6期1650-1659,共10页Chinese Traditional and Herbal Drugs

基　　金：国家“重大新药创制”科技重大专项(2018ZX09201011)。

摘　　要：生物碱类成分是自然界存在最广泛的天然产物之一,大多具有驳杂的环状结构,具有降血糖、抗肿瘤、抗菌、抗病毒等多种药理活性,是中药中最重要的有效成分。大孔树脂是一种不能溶于酸、碱和多种有机溶剂的高分子聚合物,具有吸附快、解吸条件平缓、再生方便、利用周期长等特点。近年来,大孔树脂在生物碱、黄酮等化合物的分离纯化领域得到了广泛应用。但因大孔树脂种类繁多,市场销售的大孔树脂质量参差不齐,影响纯化效果的因素繁杂,给实验研究带来很大影响。对近年来大孔树脂用于分离富集生物碱类成分的研究现状进行介绍,归纳大孔树脂分离纯化效果的主要影响因素,总结用于富集生物碱类成分的大孔树脂特点,进而分析目前大孔树脂工业应用存在的问题,研究大孔树脂预处理和再生工艺,通过优化过程参数,加强吸附-解吸性能,从而提高目标生物碱的产量和回收率,进一步促进大孔树脂在生物碱类成分分离纯化中的应用。Alkaloids is one of the most extensive natural products and one of the most important effective constituents of Chinese materia medica(CMM), most of which have complex ring structure and the effect of antidiabetics, antitumor, antibacterial, antiviral and so on. Macroporous resin is a kind of high-molecular polymer, which cannot be dissolved in acid, alkali and a variety of organic solvents, with the feature of fast adsorption and mild desorption condition, easy regeneration, and long service cycle, etc. In recent years, macroporous resin has been widely applied to the separation and purification of alkaloids and flavonoids. However, there are so many different kinds and variable quality of macroporous resin in the market, as well as multifarious factors influencing the purification effect, the experimental research has been severely affected. In this paper, the application of macroporous resin on separating and enriching alkaloids in recent years had been studied to summarize the main factors affecting the purification effect. The characteristics as well as the problems of macroporous resin were also analyzed. By studying the pretreatment and regeneration process of macroporous resin and optimizing process parameters, the adsorption and desorption performance can be strengthened and the yield or recovery rate of target alkaloids could be enhanced, promoting the further use of macroporous resin in separating and enriching alkaloids from CMM.

关 键 词：大孔树脂 吸附 生物碱 影响因素 自动控制 

分 类 号：R284.11[医药卫生—中药学]