卵巢不敏感综合征不孕患者助孕病例分析及文献回顾  

Case analysis and literature review of resistant ovary syndrome infertility

作　　者：杨蕊[1] 王颖[1] 张春梅[1] 李蓉[1] 刘平[1] 乔杰[1] Yang Rui;Wang Ying;Zhang Chunmei;Li Rong;Liu Ping;Qiao Jie(Reproductive Medical Center,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院生殖医学中心,100191

出　　处：《中华生殖与避孕杂志》2020年第1期45-49,共5页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金(81501324、81550022)。

摘　　要：目的 结合既往文献及临床病例,总结卵巢不敏感综合征(ROS)诊疗特征.方法 回顾性分析北京大学第三医院生殖中心4例有生育要求的ROS病例特点及临床诊治特征.结果 不孕患者ROS的诊治往往曲折而成效有限.积极助孕失败的ROS患者基础卵泡刺激素(FSH)水平升高明显,往往>40 IU/L,甚至高于100 IU/L,或存在长时间闭经;下丘脑-垂体轴功能良好.促性腺激素释放激素类似物(GnRHa)长方案或超长方案、体外成熟(IVM)技术是ROS患者可选择的助孕方案.结论 体外受精助孕技术仍然是对于此类患者可能妊娠的有效治疗方法,可以积极尝试GnRHa长/超长方案/IVM方案助孕.Objective To summarize the diagnosis and treatment characteristics of resistant ovary syndrome(ROS)combined with previous literature and clinical cases.Methods The clinical characteristics of 4 cases of ROS with reproductive requirements was retrospectively in Reproducrive Medical Center of Peking University Third Hospital.Results The diagnosis and treatment of infertility ROS is often tortuous and limited.ROS patients with treatment failure often has significantly increased follicle stimulating hormone(FSH),which is more than 40 IU/L,or even more than 100 IU/L,and they often had long-term amenorrhea;the hypothalamic pituitary axis function was normal.Gonadotropin-releasing hormone analogue(GnRHa)long or pro-longed protocol,and in vitro maturation(IVM)are optional protocol.Conclusion In vitro fertilization is still an effective treatment for ROS patients for successful pregnancy.We can actively try GnRHa long/pro-longed/IVM protocol.

关 键 词：卵巢不敏感综合征 辅助生殖 卵巢刺激 体外成熟 

分 类 号：R714.8[医药卫生—妇产科学]