PDFF和OP/IP对胸、腰椎多发性骨髓瘤骨病的诊断价值  

Diagnostic Value of PDFF and OP/IP for Multiple Myeloma Bone Disease of Thoracic and Lumbar Spine

作　　者：魏铃 王丰哲[1] 殷国良 潘诗农[1] WEI Ling;WANG Fengzhe;YIN Guoliang;PAN Shinong(Department of Radiology,Shengjing Hospital,China Medical University,Shenyang 110000,China)

机构地区：[1]中国医科大学附属盛京医院放射科,沈阳110000

出　　处：《肿瘤防治研究》2020年第2期115-118,共4页Cancer Research on Prevention and Treatment

摘　　要：目的探讨化学位移水脂磁共振成像的质子密度脂肪分数(PDFF)和同、反相位成像(OP/IP)对胸、腰椎多发性骨髓瘤骨病(MMBD)的诊断价值。方法所有MMBD患者均行脊柱矢状位T1WI、矢状位STIR、矢状位mDxion quant和矢状位mDxion FFE扫描。将正常椎体及良性病变椎体并为非MMBD病变组,MMBD病变椎体为MMBD病变组,分别测量PDFF值和OP/IP值;进行两独立样本t检验,采用受试者工作特征(ROC)曲线评估两参数对MMBD的诊断效能,用Youden指数法计算OP/IP和PDFF的诊断临界值;利用Pearson检验分析两参数的相关性。结果MMBD病变组的PDFF明显低于非MMBD病变组,OP/IP明显高于非MMBD病变组,差异均有统计学意义(均P<0.05)。PDFF和OP/IP的诊断界值分别为8.45%和0.66,PDFF的ROC曲线下面积(AUC)(0.969)>OP/IP(0.922),两者的敏感度分别为96.64%和85.71%,特异性分别为96.35%和90.41%。两者的AUC差异有统计学意义(P=0.007)。PDFF与OP/IP呈中度负相关。结论PDFF和OP/IP对于MMBD的诊断均有一定价值,PDFF的诊断效能优于OP/IP。Objective To investigate the diagnostic value of proton density fat fraction(PDFF)and in phase and out of phase imaging(OP/IP)for thoracic and lumbar multiple myeloma bone disease(MMBD).Methods All patients underwent spinal MRI,including sagittal T1WI,sagittal STIR,sagittal mDxion quant and sagittal mDxion FFE.The normal vertebrae and benign lesion vertebrae were non-MMBD lesion group,and the MMBD lesion vertebrae was MMBD lesion group,and the PDFF and OP/IP value were measured respectively.Two independent sample t-tests were performed,and the receiver operating characteristic(ROC)curve was used to evaluate the diagnostic performance of the two parameters for MMBD;the Pearson test was used to analyze the correlation between the two parameters.The diagnostic cutoff value of OP/IP and PDFF were calculated by Youden index method.Results The PDFF of the MMBD lesion group was lower while the OP/IP was higher than those of the non-MMBD lesion group(both P<0.05).The diagnostic cutoff values,the area under the ROC curve(AUC),the sensitivity,the specificity of PDFF and OP/IP were 8.45%and 0.66,0.969 and 0.922,96.64%and 85.71%,96.35%and 90.41%,respectively.The difference in AUC between two groups was statistically significant(P=0.007).MMBD was moderately negatively correlated with OP/IP.Conclusion PDFF and OP/IP have certain value for the diagnosis of MMBD.The diagnostic performance of PDFF is better than OP/IP.

关 键 词：多发性骨髓瘤 诊断 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R733.3[医药卫生—诊断学]