药物树脂复合物的表面包衣法微囊化工艺  

Microencapsulation Process of Drug-resinates by Surface Coating Technology

作　　者：黄艳 陈振阳 曾环想 程刚[2] 潘卫三[2] HUANG Yan;CHEN Zhenyang;ZENG Huanxiang;CHENG Gang;PAN Weisan(Sinopharm Zhijun(Shenzhen)Pharmaceutical Co.,Ltd.,Shenzhen 518110;College of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016)

机构地区：[1]国药集团致君(深圳)制药有限公司,广东深圳518110 [2]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国医药工业杂志》2020年第3期381-386,共6页Chinese Journal of Pharmaceuticals

摘　　要：以马来酸氯苯那敏为模型药物,采用离子交换树脂(Amberlite IRP-69)为载体制备药物树脂复合物。再以丙烯酸树脂(Eudragit RS100)为包衣材料,通过离子交换的方式对氯苯那敏树脂复合物进行表面包衣,并对表面包衣工艺参数的影响进行单因素考察,以期制备具有良好缓释性能的氯苯那敏树脂复合物微囊。在本试验范围内,药物树脂复合物的载药量越高、Eudragit RS100浓度越高、反应介质(95%乙醇)用量越多以及反应温度越高,药物释放越慢。上述结果提示,表面包衣法制备药物树脂复合物缓释微囊的生产操作简单,工艺重现性好,可进一步作制剂加工。Chlorphenamine maleate(CPM)was used as a model drug to prepare drug-resinates using ion exchange resin(Amberlite IRP-69)as a carrier.Then,the microcapsules loaded with drug-resinates with acrylic resin(Eudragit RS100)as a surface coating material were prepared by the surface coating technology via ion exchange reactions.The process parameters of the surface coating technology were investigated to prepare the microcapsules loading drug-resinates with good sustained-release properties.The results of a single factor test showed that the higher drug-loading of the drug-resinates was,the slower drug released from the microcapsules.The similar phenomena occurred in the investigations of Eudragit RS100 concentration,the amount of reaction medium(95%ethanol)and reaction temperature.These results indicated that the surface coating technology was simple and reproducible,and the obtained microcapsules of drug-resinates with good sustained-release properties could be further processed as a pharmaceutical preparation.

关 键 词：马来酸氯苯那敏 离子交换树脂 丙烯酸树脂 缓释微囊 表面包衣法 

分 类 号：R944.9[医药卫生—药剂学]