河源地区健康人血清抗环瓜氨酸肽抗体水平参考区间的研究  

Study on the reference range of anticycline peptide antibody level in healthy human serum in Heyuan area

作　　者：钟国权 曾泽霞 高雪武 何雪爱 Zhong Guoquan;Zeng Zexia;Gaoxuewu;He Xueai(Department of Clinical Laboratory,Peoples Hospital of Yuancheng district,Heyuan City,Guangdong 517000,China;不详)

机构地区：[1]广东省河源市源城区人民医院检验科,517000 [2]广东省河源市源城区人民医院内科,517000 [3]广东省河源市源城区人民医院体检中心,517000

出　　处：《实用医技杂志》2020年第2期157-159,共3页Journal of Practical Medical Techniques

基　　金：广东省河源市社会发展科技计划项目(170524150-220513)。

摘　　要：目的探讨河源地区健康成年人血清抗环瓜氨酸肽(CCP)抗体水平否存在年龄和性别的差异,以了解河源地区健康人群抗CCP抗体的血清水平分布情况,为相关疾病的诊断及治疗提供相应实验室数据,拟建立本室的血清抗CCP抗体参考范围。方法选取2015年4月至2019年4月在我院体检中心体格检查的健康人群917名,入选对象近2年内自我感觉无不适,实验室各项数据指标、心电图、直接数字化X射线摄影(DR)检查均无明显异常,按性别分为男性组及女性组,按年龄段不同分为:A组为<20岁、B组为20~<30岁、C组为30~<40岁、D组为40~<50岁、E组为50~<60岁、F组为≥60岁共6个年龄组,采用日立7600全自动生化分析仪测定血清中抗CCP抗体水平,所得的数据进行统计学处理。结果抗CCP抗体随年龄的增长略有增加,但相邻各年龄组间比较、A组与F组比较差异均无统计学意义(P>0.05);男性组血清抗CCP抗体水平为(0.07~29.50)U/mL,女性组血清抗CCP抗体水平为(0.25~30.00)U/mL;2组间相比较差异无统计学意义(P>0.05)。结论年龄、性别对抗CCP抗体水平的分布差别不大,不同性别及年龄的健康人群可建立同一参考区间。采用百分位数法,用P2.5~P97.5估计95%双侧正常参考区间范围,P5~P95为95%单侧正常参考区间范围;确定我室健康人群参考区间上限为≤30 U/mL;31~44 U/mL为可疑,≥45 U/mL为阳性。Objective To investigate the difference in age and sex of anticyclocitrulline peptide(CCP)antibody levels in healthy adults in heyuan area,in order to understand the distribution of anti-CCP antibody levels among Healthy people in heyuan area.To provide relevant laboratory data for the diagnosis and treatment of related diseases,it is planned to establish the reference range of the serum anti-CCP antibody in this room.Methods Nine hurdreds and seventeen healthy people were selected from April 2015 to April 2019 for physical examination at the physical examination center of our hospital.Within the past year,the selected subjects felt no discomfort.There were no obvious abnormalities in various data indicators,electrocardiograms,and DR examinations in the laboratory.Male and female groups,divided by age group:Group A is:<20 years old,group B is:20-<30 years old,group C is:30-<40 years old,Group D is:40-<50 years old,Group E is:50-<60 year-old and F group were:≥60 year-old total of 6 age groups,and Hitachi 7600 automatic biochemical analyzer was used to determine the level of anti-CCP antibody in the serum,and the resulting data was statistically processed.Results There was a slight increase with age,but there was no significant difference between adjacent age groups and between Group A and Group F(P>0.05);the level of anti-CCP antibody in the male group was(0.07-29.50)U/mL,and the level of anti-CCP antibody in the female group was(0.25-30.00)U/mL;there was no statistically significant difference between the two groups(P>0.05).Conclusion The distribution of anti-CCP antibody levels by age and gender is not different,and healthy people of different gender and age can establish the same reference range.The percentage method is used to estimate 95%of the normal reference range on both sides with P2.5 to P97.5,and P5 or P95 is 95%of the normal reference range on one side;Determine that the upper limit of the reference range for the healthy population in our room is≤30 U/mL;31-44 U/mL is suspicious and≥45 U/mL is p

关 键 词：抗环瓜氨酸肽抗体 健康记录 个人 参考区间 

分 类 号：R593.22[医药卫生—内科学]