疏肝清胆汤联合熊去氧胆酸片治疗肝胆湿热型慢性胆囊炎临床研究  

Clinical Study on Shugan Qingdan Tang Combined with Ursodeoxycholic Acid Tablets for Chronic Cholecystitis of Liver-gallbladder Damp-heat Type

作　　者：郭海军 郭秀霞 王本贤 GUO Haijun;GUO Xiuxia;WANG Benxian

机构地区：[1]周口市中医院,河南周口466000

出　　处：《新中医》2020年第5期77-80,共4页New Chinese Medicine

基　　金：河南省中医药管理局专项课题(2016ZY3480)。

摘　　要：目的:观察疏肝清胆汤联合熊去氧胆酸片治疗肝胆湿热型慢性胆囊炎的临床疗效。方法:选取100例肝胆湿热型慢性胆囊炎患者,按随机数字表法分为对照组和观察组各50例。对照组给予熊去氧胆酸片治疗,观察组给予疏肝清胆汤联合熊去氧胆酸片治疗,2组均连续治疗4周。观察治疗前后症状、体征的变化,评价疗效,检测总胆汁酸(TBA)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和甘胆酸(GC)水平。结果:观察组总有效率94.00%,对照组总有效率76.00%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组主症评分、次症评分和总分均较治疗前降低,观察组主症评分、次症评分和总分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组GC及TBA含量均较治疗前降低,且均低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组TC、TG、LDL-C水平均较治疗前降低,HDLC水平均较治疗前升高,差异均有统计学意义(P<0.05);观察组TC、TG、LDL-C水平均低于对照组,HDL-C水平高于对照组,差异均有统计学意义(P<0.05)。2组均未见明显不良反应。结论:疏肝清胆汤联合熊去氧胆酸片治疗肝胆湿热型慢性胆囊炎疗效显著,能有效改善患者的症状,调节GC、TBA及血脂水平,安全性高。Objective:To observe the clinical effect of Shugan Qingdan tang combined with ursodeoxycholic acid tablets for chronic cholecystitis of liver-gallbladder damp-heat type.Methods:A total of 100 cases of patients with chronic cholecystitis of liver-gallbladder damp-heat type were randomly divided into the control group and the observation group according to the random number table method,50 cases in each group.The control group was treated with ursodeoxycholic acid tablets,and the observation group was additionally treated with Shugan Qingdan tang based on the treatment of the control group.Both groups were treated for four weeks.Before and after treatment,the changes of symptoms and signs were observed.The curative effect was evaluated.The levels of total bile acid(TBA),total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and glycocholic acid(GC)were detected.Results:The total effective rate was 94.00%in the observation group and 76.00%in the control group,the difference being significant(P<0.05).After treatment,the scores of main and secondary symptoms and the total scores in the two groups were decreased when compared with those before treatment,and the above scores in the observation group were lower than those in the control group,differences being significant(P<0.05).After treatment,the content of GC and TBA in the observation group was decreased when compared with that before treatment,and was lower than that in the control group,differences being significant(P<0.05).After treatment,the levels of TC,TG and LDL-C in the two groups were decreased when compared with those before treatment,and the levels of HDL-C were increased,differences being significant(P<0.05);the levels of TC,TG and LDL-C in the observation group were lower than those in the control group,and the level of HDL-C was higher,differences being significant(P<0.05).There was no obvious adverse reaction being found in both groups.Conclusion:The therapy of Shugan Qingdan tang c

关 键 词：慢性胆囊炎 肝胆湿热证 疏肝清胆汤 熊去氧胆酸片 总胆汁酸(TBA) 甘胆酸(GC) 血脂 

分 类 号：R657.41[医药卫生—外科学]