阿司匹林和低分子肝素治疗习惯性流产临床疗效及对抗体清除率影响  

Clinical Efficacy of Aspirin and LMWH in the Treatment of Habitual Abortion and Effect of Antibody Clearance Rate

作　　者：赵娜[1] ZHAO Na(The Third Affiliated Hospital of Zhengzhou University,Zhengzhou Henan 450000,China)

机构地区：[1]郑州大学第三附属医院产科,河南郑州450000

出　　处：《临床研究》2020年第4期40-41,共2页Clinical Research

摘　　要：目的探讨阿司匹林和低分子肝素治疗习惯性流产的临床疗效。方法选择2016年1月-2018年7月郑州大学第三附属医院习惯性流产患者90例,随机分为两组,各45例。对照组给予阿司匹林治疗,观察组给予阿司匹林+低分子肝素治疗,比较保胎成功率、抗体清除率、流产率、早产率、血液流变学指标、不良反应。结果观察组的保胎成功率、抗体清除率均较对照组更高,其流产率、早产率均较对照组更低,其治疗后的红细胞压积、红细胞沉降率、血浆粘度均较对照组更低,均P<0.05。组间不良反应总发生率比较无统计学差异(P>0.05)。结论阿司匹林与低分子肝素联合用于习惯性流产患者中,可有效提高抗体清除率和保胎成功率,安全性良好。Objective To investigate the clinical efficacy of aspirin and LMWH in the treatment of habitual abortion.Methods 90 cases of patients with habitual abortion admitted to our hospital from January 2016 to July 2018 were selected and randomLy divided into two groups,45 cases in each group.The control group was given aspirin treatment,and the observation group was given aspirin plus LMWH treatment.The success rate of fetal protection,antibody clearance rate,abortion rate,premature delivery rate,hemorheological indexes and adverse reactions were compared.Results The success rate and antibody clearance rate of the observation group were higher than those of the control group,the abortion rate and premature delivery rate of the observation group were lower than those of the control group,the hematocrit,erythrocyte sedimentation rate and plasma viscosity after treatment of the observation group were lower than those of the control group,all P<0.05.There was no significant difference in the total incidence of adverse reactions between two groups(P>0.05).Conclusion The combination of aspirin and LMWH in patients with habitual abortion can effectively improve the rate of antibody clearance and the success rate of fetal preservation and there was a good safety.

关 键 词：妇产科 习惯性流产 阿司匹林 低分子肝素 

分 类 号：R714.21[医药卫生—妇产科学]