BiPAP无创呼吸机联合尼可刹米治疗AE-COPD合并Ⅱ型呼吸衰竭和重度高碳酸血症的临床效果观察  

To explore the clinical study of BiPAP non-invasive ventilator combined with nicosamide in the treatment of AECOPD with type II respiratoryfailure and severe hypercapnia

作　　者：文素芳 梁刚 黄世强 Wen Sufang;Liang Gang;Huang Shiqiang(No.4 People's Hospital of Yibin City,Yibin,Sichuan 644000,China)

机构地区：[1]宜宾市第四人民医院,四川宜宾644000

出　　处：《医药前沿》2020年第4期53-54,共2页Journal of Frontiers of Medicine

摘　　要：目的:探讨双水平气道正压(BiPAP)无创呼吸机联合尼可刹米治疗慢性阻塞性肺疾病急性加重期(AE-COPD)合并Ⅱ型呼吸衰竭(RF-Ⅱ)和重度高碳酸血症(PHY)患者的临床疗效。方法:选取就诊于我院的118例AE-COPD合并RF-Ⅱ和PHY的患者,按双盲法将患者分为实验组和对照组,各59例。两组均给予常规治疗,对照组在其基础上采用BiPAP无创呼吸机治疗,实验组在对照组基础上联合尼可刹米治疗。结果:两组治疗前PaO2、PaCO2和pH水平对比无显著差异(P>0.05);两组治疗后PaO2、PaCO2和pH水平均有所改善且实验组改善程度优于对照组(P<0.05);实验组治疗总有效率高于对照组(P<0.05)。结论:AE-COPD合并RF-Ⅱ和PHY患者以BiPAP无创呼吸机联合尼可刹米治疗效果显著,值得应用。Objective To investigate the clinical efficacy of bi-level positive airway pressure noninvasive ventilator combined with nicosamide in the treatment of chronic obstructive pulmonary disease.Methods 118 patients with AE-COPD and RF-II and PHY were selected by random sampling method.According to double blind method,the patients were divided into experimental group and control group,59 cases in each group.Both groups were given routine treatment,the control group was treated with BiPAP non-invasive ventilator on the basis of which,the experimental group was treated with nicosamide.Results There was no significant difference in the levels of PaO2,PaCO2 and pH between the two groups before treatment(P>0.05);the levels of PaO2,PaCO2 and pH were improved after treatment in both groups,and the improvement degree of the experimental group was better than that of the control group(P<0.05);the total effective rate of the experimental group was higher than that of the control group(P<0.05).Conclusion BiPAP noninvasive ventilator combined with nicosamide is worthy of application in AE-COPD,RF-II and PHY.

关 键 词：双水平气道正压 无创呼吸机 尼可刹米 慢性阻塞性肺疾病急性加重期 Ⅱ型呼吸衰竭 重度高碳酸血症 

分 类 号：R563[医药卫生—呼吸系统]