中药熏蒸疗法对气滞血瘀型原发性痛经患者PGE2、PGF2α、β-EP的影响  

Effect of Traditional Chinese Medicine Fumigation Therapy on PGE2 PGF2αandβ-EP in Primary Dysmenorrhea Patients with qi Stagnation and Blood Stasis

作　　者：周倩[1] ZHOU Qian(Suzhou University Hospital,Suzhou,Jiangsu 215000,China)

机构地区：[1]苏州大学医院,江苏苏州215000

出　　处：《大医生》2019年第23期92-95,共4页Doctor

摘　　要：目的 研究中药熏蒸疗法对气滞血瘀型原发性痛经患者血清前列腺素E2(PGE2)、前列腺素F2α(PGF2α)、β-内啡肽(β-EP)的影响.方法 选取苏州大学医院妇科2018年1月至2019年6月收治的68例气滞血瘀型原发性痛经患者为研究对象,按照数字表法随机分为参照组和观察组,各34例.参照组予以布洛芬口服进行治疗,观察组在参照组的基础上加用中药熏蒸疗法进行治疗,治疗周期为2个月.比较2组治疗后临床疗效,比较2组治疗前后的中医症状积分及血清PGE2、PGF2α、β-EP水平变化,并观察2组治疗过程中不良反应发生情况.结果 观察组总有效率为91.17%,显著高于参照组的(67.65%,P<0.05);与治疗前比,治疗后2组食欲不振、头晕头痛、乳房胀痛、腰骶酸痛及四肢发冷积分均降低,且观察组显著低于参照组(P<0.05);与治疗前比,治疗后2组血清PGE2、β-EP水平均升高,且观察组显著高于参照组,血清PGF2α水平均降低,且观察组显著低于参照组(P<0.05);观察组不良反应发生率为2.94%,显著低于参照组的(17.64%,P<0.05).结论 中药熏蒸疗法可有效调节气滞血瘀型原发性痛经患者血清PGE2、PGF2α、β-EP水平,缓解临床症状,疗效显著,且不良反应少,安全可靠.Objective To study the Effect of traditional Chinese medicine fumigation therapy on PGE2,PGF2αandβ-EP in primary dysmenorrhea patients with qi stagnation and blood stasis.Methods Totally 34 patients with primary dysmenorrhea of qi stagnation and blood stasis type treated in the Department of Gynecology of Suzhou University Hospital from January 2018 to June 2019 were selected as the research objects,and randomly divided into a reference group and an observation group according to the numerical table method,with 34 cases each,reference The group was treated with ibuprofen,and the observation group was treated with Chinese medicine fumigation therapy on the basis of the reference group.The treatment period was 2 months.Compare the clinical efficacy of the two groups after treatment,compare the TCM symptom scores and changes in serum PGE2,PGF2α,β-EP levels before and after the two groups,and observe the occurrence of adverse reactions during the treatment of the two groups.Results The total effective rate of the observation group was 91.17%,significantly higher than that of the control group(67.65%,P<0.05).Compared with the pre-treatment group,the scores of loss of appetite,dizziness,headache,breast tenderness,lumbosacral soreness and limb chills in the two groups decreased after treatment,and the scores in the observation group were significantly lower than that in the control group(P<0.05).Compared with the comparison before treatment,the serum PGE2 and blaze-ep levels of the two groups increased after treatment,and the observation group was significantly higher than the control group,while the serum PGF2 levels of the observation group were significantly lower than that of the control group(P<0.05).The incidence of adverse reactions in the observation group was 2.94%,significantly lower than 17.64%in the control group(P<0.05).Conclusion Traditional Chinese medicine fumigation therapy can effectively regulate the serum levels of PGE2,PGF2,doh-ep in patients with primary dysmenorrhea of qi stagnation and blood

关 键 词：气滞血瘀 原发性痛经 中药熏蒸疗法 前列腺素E2 前列腺素F2Α β-内啡肽 

分 类 号：R27[医药卫生—中医学]