微小RNA对老年冠心病慢性心力衰竭合并高血压的影响  

Effect of microRNA on chronic heart failure in elderly coronary heart disease patients with hypertension

作　　者：尹涛源 林玲[1] 杨大英[1] 杜永才[1] 彭兴[1] 孙加凤[2] Yin Taoyuan;Lin Ling;Yang Daying;Du Yongcai;Peng Xing;Sun Jiafeng(Department of Cardiology,Sanya Central Hospital,Sanya 572000,Hainan Province,China)

机构地区：[1]三亚中心医院,海南省第三人民医院心血管内科,572000 [2]三亚中心医院,海南省第三人民医院内分泌科,572000

出　　处：《中华老年心脑血管病杂志》2020年第4期385-388,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的探讨微小RNA对老年冠心病慢性心力衰竭(CHF)合并高血压的影响。方法连续收集2017年1月~2019年1月于我院收治的原发性高血压患者520例,根据患者是否合并CHF,分为CHF组178例和对照组342例,观察2组患者微小RNA谱(微小RNA-1、-21、-23、-29、-30、-130、-133、-195、-199、-208和-320)表达的差异,用Pearson相关性分析,用多因素logistic回归分析影响因素。结果与对照组比较,CHF组患者收缩压和舒张压明显增高[(166.85±12.75)mm Hg vs(158.74±13.71)mm Hg(1 mm Hg=0.133 kPa),P=0.000、(105.73±14.83)mm Hg vs(98.47±10.75)mm Hg,P=0.000];LVEF明显降低[(41.74±5.75)%vs(57.85±6.02)%,P=0.000];且CHF组微小RNA-1、微小RNA-21、微小RNA-23、微小RNA-29、微小RNA-130、微小RNA-195、微小RNA-199相对表达量增加(P<0.05)。2组微小RNA-30、微小RNA-133、微小RNA-208、微小RNA-320相对表达量比较,均无统计学差异(P>0.05)。微小RNA-1、微小RNA-21、微小RNA-23、微小RNA-29、微小RNA-130、微小RNA-195、微小RNA-199相对表达量与LVEF呈显著负相关(P<0.01)。多因素logistics回归分析显示,微小RNA-1、微小RNA-21、微小RNA-23、微小RNA-29、微小RNA-130、微小RNA-195、微小RNA-199相对表达量增加是CHF的影响因素(P<0.05,P<0.01)。结论微小RNA-1、微小RNA-21、微小RNA-23、微小RNA-29、微小RNA-130、微小RNA-195、微小RNA-199表达量增加可能与冠心病的老年患者并发CHF有关。Objective To study the effect of microRNA(miR)on chronic heart failure(CHF)in elderly coronary heart disease(CHD)patients with hypertension.Methods Five hundred and twenty CHD patients with essential hypertension admitted to our hospital from January 2017 to January 2019 were divided into CHF group(n=178)and control group(n=342).The expressions of miR were detected,including miR-1,miR-21,miR-23,miR-29,miR-30,miR-130,miR-133,miR-195,miR-199,miR-208 and miR-320.The relationship between miR expression and CHF in CHD patients with essential hypertension were analyzed by Pearson correlation analysis.The influencing factors of CHF in CHD patients with essential hypertension were analyzed by multivariate logistic regression analysis.Results The systolic blood pressure and diastolic blood pressure were significantly higher while the LVEF was significantly lower in CHF group than in control group(166.85±12.75 mm Hg vs 158.74±13.71 mm Hg,P=0.000;105.73±14.83 mm Hg vs 98.47±10.75 mm Hg,P=0.000;41.74%±5.75%vs 57.85%±6.02%,P<0.05).The expression levels of miR-1,miR-21,miR-23,miR-029,miR-130,miR-195,and miR-199 were significantly higher in CHF group than in control group(P<0.05).No significant difference was detected in expression levels of miR-30,miR-133,miR-208 and miR-320 between the two groups(P>0.05).The expression levels of miR-1,miR-21,miR-23,miR-029,miR-130,miR-195 and miR-199 were negatively related with the LVEF(P<0.01).Multivariate logistic regression analysis showed that elevated expression levels of miR-1,miR-21,miR-23,miR-29,miR-130,miR-195 and miR-199 were the risk factors for CHF in elderly CHD patients with essential hypertension(P<0.05).Conclusion Elevated expression levels of miR-1,miR-21,miR-23,miR-29,miR-130,miR-195 and miR-199 are the risk factors for CHF in elderly CHD patients with essential hypertension.

关 键 词：微RNAS 冠心病 心力衰竭 高血压 基因表达 心室重构 

分 类 号：R544.1[医药卫生—心血管疾病] R541.4[医药卫生—内科学] R541.6[医药卫生—临床医学]