髓系细胞触发受体-1在脓毒症心肌功能障碍中作用的研究进展  

Role of triggercing receptor expressed on myeloid cell-1 in septic myocardial dysfunction

作　　者：潘晓燕 邓烈华 PAN Xiaoyan;DENG Liehua(Grade 2017,Guangdong Medical University,Zhanjiang524000,China;Department of Critical Medicine,Affiliated Hospital of Guangdong Medical University,Zhanjiang524000,China)

机构地区：[1]广东医科大学,广东湛江524000 [2]广东医科大学附属医院危重症医学科,广东湛江524000

出　　处：《中华实用诊断与治疗杂志》2020年第3期318-320,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金(81974298)。

摘　　要：髓系细胞触发受体-1(triggering receptor expressed on myeloid cell-1, TREM-1)在实质细胞表达较少,主要表达于大多数天然免疫细胞,其激活后可通过Toll样受体4(Toll-like receptor 4, TLR4)通路直接或间接放大炎性反应,参与多种急、慢性炎症疾病的病理过程。TLR4通路在脓毒症心肌功能障碍发病中发挥重要作用。TREM-1可加重脓毒症模型动物心功能障碍,可溶性TREM-1水平与脓毒症心肌功能障碍密切相关。本文就TREM-1的表达形式、可能配体及在脓毒症、脓毒症心肌功能障碍中作用的研究进展作一综述。Triggering receptor expressed on myeloid cell-1(TREM-1) is mainly expressed in most natural immune cells, but less expressed in parenchymal cells. After its activation, it can directly or indirectly amplify the inflammatory response through the synergistic effect of Toll-like receptor 4, and participate in the pathological process of various acute and chronic inflammatory diseases. Toll-like receptor 4 pathway plays an important role in the pathogenesis of septic myocardial dysfunction. TREM-1 can aggravate myocardial dysfunction in septic animals.The level of soluble TREM-1 is closely correlated with septic myocardial dysfunction. This paper reviews the research progress of the expression form, possible ligands of TREM-1 and its role in sepsis and septic myocardial dysfunction.

关 键 词：脓毒症 心肌功能障碍 髓系细胞触发受体-1 

分 类 号：R459.7[医药卫生—急诊医学]