心踝血管指数和踝臂指数与高血压合并颈动脉硬化关系的研究  

Relationship of Cardio-ankle Vascular Index and Ankle-brachial Index in Essential Hypertensives with Carotid Arteriosclerosis

作　　者：贾芳 金哲秀 黄蕾 熊强 JIA Fang;JIN Zhe-xiu;HUANG Lei;XIONG Qiang(Department of Cardiology,The Second Affi liat ed Hospital of Xiamen Medical College,Xiamen 361021,China)

机构地区：[1]厦门医学院附属第二医院心内科,福建厦门361021

出　　处：《中国医药指南》2020年第10期10-11,14,共3页Guide of China Medicine

摘　　要：目的观察心踝血管指数、踝臂指数和高血压患者颈动脉内膜中层厚度之间的关系。方法原发性高血压患者共130例,测量心踝血管指数(CAVI)、踝臂指数(ABI)、颈动脉内膜中层厚度(IMT)、血压、血脂等参数。130例高血压患者先根据CAVI分成CAVI正常组(n=44)和CAVI异常组(n=86);再依照ABI分成ABI正常组(n=58)和ABI异常组(n=72)。探讨CAVI、ABI与IMT的关系以及影响CAVI、ABI的因素。结果CAVI和ABI异常组的血压、IMT均比正常组高,差别有统计学意义(P<0.05),直线相关分析提示:CAVI与IMT显著正关联,ABI与IMT显著负关联。同时进行多元逐步回归分析提示:CAVI与年龄、SBP、TC、LDL-C显著正相关(P<0.05),ABI与年龄、SBP、TC、LDL-C显著负相关(P<0.05)。结论CAVI和ABI可以作为评估高血压患者颈动脉硬化的良好参考指标,影响CAVI、ABI的要素主要是年龄、SBP、TC、LDL-C,其中年龄对CAVI、ABI的影响最大。Objective To investigate the relationship of cardio-ankle vascular index and ankle-brachial index in essential hypertensives with carotid arteriosclerosis.Methods(First,one hundred and thirty essential hypertensives were divided into two groups:normal cardio-ankle vascular index group(n=44)and abnormal cardio-ankle vascular index group(n=86).Then,one hundred and thirty essential hypertensives were divided into two groups:normal ankle-brachial index group(n=58)and abnormal ankle-brachial index group(n=72).The indicatrix of cardio-ankle vascular index(CAVI),anklebrachial index(ABI),carotid artery intima-media thickness(IMT),blood pressure and lipidemia were measured respectively.To investigate the relationship between CAVI,ABI and the IMT,at the same time,to investigate the infl uenc factor of CAVI and ABI.Results Blood pressure and IMT were signifi cantly increased in abnormal CAVI and abnormal ABI group compared with normal group.Straight line correlation analysis resulr indicate:CAVI was signifi cant positive related with IMT,ABI was signifi cant negativel related with IMT.Results were analyzed by multivariable logistic regression model,CAVI was positively related with age,systolic pressure,total cholesterol(TC),low density lipoprotein-cholesterin(LDL-C).Conclusion CAVI and ABI were sensitive indicators which can predict essential hypertensives with carotid arteriosclerosis.Infl uence factors about CAVI and ABI were age,systolic pressure,TC,LDL-C,among these,age was the signifi cant Infl uence factor.

关 键 词：高血压 心-踝血管指数 踝臂指数 颈动脉内膜中层厚度 

分 类 号：R544.1[医药卫生—心血管疾病]