米格列奈联合地特胰岛素治疗新诊断2型糖尿病的临床观察  

Clinical Observation of Mitiglinide Combined with Insulin Detemir in the Treatment of Newly Diagnosed Type 2 Diabetes

作　　者：邵红维 SHAO Hong-wei(Central Hospital of Kalaqin Left-wing Mongolian Autonomous County,Chaoyang 122300,China)

机构地区：[1]辽宁省喀喇沁左翼蒙古族自治县中心医院,辽宁朝阳122300

出　　处：《中国医药指南》2020年第10期95-96,共2页Guide of China Medicine

摘　　要：目的分析评价新诊断2型糖尿病采取米格列奈联合地特胰岛素治疗的临床疗效。方法本次采取随机数字表法,将我院于2017年12月至2018年12月收治的84例新诊断2型糖尿病患者分成两组,每组平均为42例;其中,对照组患者采取预混人胰岛素注射液治疗,观察组患者采取米格列奈联合地特胰岛素治疗,进一步对两组临床治疗效果进行对比评价。结果①观察组治疗总有效率高达95.24%,和对照组的71.43%对比显著要高(P<0.05)。②在空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)三项血糖指标水平方面,治疗前两组比较无明显差异(P>0.05);经有效治疗之后,在以上三项血糖指标水平方面,观察组的改善效果与对照组对比明显更优,两组数据之间存在显著差异性(P<0.05)。③在血糖达标时间方面,观察组与对照组比较明显更快(P<0.05);从胰岛素用量方面来看,观察组与对照组比较明显更少(P<0.05)。此外,在低血糖发生率方面,观察组仅为4.76%,和对照组的26.19%对比显著要低(P<0.05)。结论在临床中,针对新诊断2型糖尿病患者,采取米格列奈联合地特胰岛素治疗的疗效显著,可改善血糖指标水平,降低低血糖发生率,进一步提高生活质量;因此,值得在临床护理工作中采纳及应用。Objective To evaluate the clinical effi cacy of miglinide combined with insulin therapy in newly diagnosed type 2 diabetes mellitus.Methods Eightyfour newly diagnosed type 2 diabetes patients admitted in our hospital from February 2017 to February 2018 were divided into 2 groups,with an average of 42 cases in each group.The patients in the control group were treated with premixed human insulin injection,and the patients in the observation group were treated with mieglinide combined with insulin.Results(1)The total effective rate of treatment in the observation group was 95.24%and that in the control group was 71.43%(P<0.05).(2)In fasting blood glucose(FPG),2 h postprandial blood glucose(2hPG)and glycosylated hemoglobin(HbA1c).There was no signifi cant difference between the two groups before treatment(P>0.05).After effective treatment,the improvement effect of the observation group was better than that of the control group,and there was signifi cant difference between the two groups(P<0.05).(3)The observation group was signifi cantly faster than the control group,and there was a signifi cant difference between the two groups(P<0.05),and there was a signifi cant difference between the two groups(P<0.05),and the insulin dosage was signifi cantly lower in the observation group than in the control group(P<0.05).In addition,the incidence of hypoglycemia in the observation group was only 4.76%,which was signifi cantly lower than that in the control group(26.19%)(P<0.05).Conclusion In clinical practice,for newly diagnosed patients with type 2 diabetes mellitus,the effect of miglinide combined with insulin therapy is signifi cant,which can improve the level of blood glucose,reduce the incidence of hypoglycemia,and further improve the quality of life.It must be adopted and applied in clinical nursing work.

关 键 词：米格列奈 地特胰岛素 新诊断2型糖尿病 治疗效果 

分 类 号：R587.1[医药卫生—内分泌]