慢性非特异性腰痛的动物模型相关研究进展  

Research progress in animal models of nonspecific low back pain

作　　者：柯嵩 徐钢 李忠海[1,2] KE Song;XU Gang;LI Zhong-hai(Department of Orthopedics,The First Affiliated Hospital,Dalian Medical University,Dalian 116600,China)

机构地区：[1]大连医科大学附属第一医院骨科,辽宁116600 [2]辽宁省骨相关疾病修复重塑分子机制重点实验室

出　　处：《中国矫形外科杂志》2020年第7期629-633,共5页Orthopedic Journal of China

基　　金：辽宁省自然科学基金指导计划项目(编号:20170540294);辽宁省高等学校基本科研项目(编号:LQ2017022);辽宁省“兴辽英才计划”项目(编号:XLYC1807131)。

摘　　要：慢性腰痛是临床上一种常见病,每年治疗慢性腰痛的医疗花费十分巨大。在慢性腰痛中,非特异性慢性腰痛占绝大部分且它的发病机制尚未明确。动物模型的制备对于了解非特异性腰痛的产生机制及作用过程具有十分重要的作用。本综述基于腰椎的解剖结构及疾病的发展机制,将非特异性腰痛动物模型分为了以下四大类:椎间盘源性、神经根性、炎症反应性以及基因相关性。同时,还部分阐述了非特异性腰痛动物模型的疼痛评估方法即反射行为学变化测试法和自发行为学变化测试法。希望通过这些动物模型的制备及研究,能深入了解非特异性腰痛的发病机理,以求在不远的将来开发出更为有效的临床治疗方案。Chronic low back pain is a common clinical disease with a huge cost of health care.In chronic low back pain,non-specific low back pain accounts for the majority,and its mechanism remains unclear.The development of animal models plays an important role in understanding the mechanism and procession of disease.This review is based on the anatomical structure of the lumbar spine and the development mechanism of the disease,divide the non-specific low back pain animal models into four categories:discogenic non-specific low back pain,radicular non-specific low back pain,inflammatory related nonspecific low back pain,and gene related non-specific low back pain.At the same time,the evaluation methods of feedback pain in animal models,including reflex behavioral change test and spontaneous behavioral change test,are briefly described in this review.It is hoped that by analyzing these animal models,we can figure out the pathogenesis and develop some better therapeutic regimens to treat the nonspecific low back pain in the future.

关 键 词：非特异性腰痛 动物模型 反射行为学变化 自发行为学变化 综述 

分 类 号：R681.57[医药卫生—骨科学]