晚钠电流与心房颤动的研究进展  

Research progress on the relationship between the cardiac late sodium current and atrial fibrillation

作　　者：赵志强[1] 李广平[1] Zhao Zhiqiang;Li Guangping(Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease,Department of Cardiology,Tianjin Institute of Cardiology,the Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津市心血管病离子与分子机能重点实验室,天津医科大学第二医院心脏科,天津心脏病学研究所,300211

出　　处：《中华老年医学杂志》2020年第3期361-364,共4页Chinese Journal of Geriatrics

基　　金：国家自然科学基金面上项目(81370300);天津市自然科学基金项目(17JCQNJC11400);天津医科大学第二医院重点实验室基金项目(2017ZDSYS05)。

摘　　要：心房颤动(房颤)是临床上最常见的心律失常之一,其发病率随增龄而增加,心脏晚钠电流增强与房颤的发生相关,抑制晚钠电流已成为抗心律失常治疗的新的靶点。晚钠电流抑制剂通过抑制心房晚钠电流发挥抗房颤作用,其独特的作用机制和较好的安全性,有可能成为房颤治疗的新策略。Atrial fibrillation is one of the most common arrhythmias.The incidence of atrial fibrillation increases with age.Increased cardiac late sodium currents are closely related to the occurrence of atrial fibrillation,and inhibition of the late sodium current has become a new target for antiarrhythmic therapy.Late sodium current inhibitors play an anti-atrial fibrillation role by inhibiting atrial late sodium currents and may become a new strategy for atrial fibrillation treatment due to their unique mechanisms and satisfactory safety.

关 键 词：钠通道 心房颤动 

分 类 号：R541[医药卫生—心血管疾病]