双孔背景钾通道TREK-1参与麻醉相关作用研究进展  

The involvement of two?pore domain K+channel TREK?1 in anesthesia

作　　者：赵帅 欧阳晔凌 胡志强 陈向东 姚尚龙[1] Zhao Shuai;Ouyang Yeling;Hu Zhiqiang;Chen Xiangdong;Yao Shanglong(Department of Anesthesiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院麻醉科,武汉430022

出　　处：《国际麻醉学与复苏杂志》2020年第1期105-110,共6页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金(81571075,81371249)。

摘　　要：TREK-1是双孔背景钾通道(tow-pore domain K^+channel,K2P)成员之一,参与调控细胞静息膜电位等,有着多种功能特性。近年来研究表明,TREK-1在麻醉、疼痛、神经保护和抑郁方面有着极其重要的作用。文章综合国内外TREK-1相关文献,简要概述TREK-1结构、功能、分布和调控,重点介绍TREK-1在上述领域的研究进展。通过进一步阐述TREK-1在麻醉、疼痛、神经保护和抑郁领域的作用,可以更好地认识TREK-1在其中的病理意义,并有助于新药物的开发。TREK-1,a member of two-pore domain K^+channel(K2P)family,has various functions and participates in the regu-lation of resting membrane potentials.Recent studies indicate that TREK-1 is essential in anesthesia,pain,neuroprotection and depres-sion.Based on domestic and foreign literature related to TREK-1,this review concisely outlines the structure,function,distribution and modulation of TREK-1,and thoroughly presents the advances in those fields above.Furthermore,the role of TREK-1 in general anes-thesia,pain,neuroprotection and depression has been elaborated,so as to provide better understanding of the pathological implication of TREK-1 in these fields and facilitate the development of new drugs.

关 键 词：TREK-1 双孔背景钾通道 麻醉 疼痛 神经保护 抑郁 

分 类 号：R614[医药卫生—麻醉学]