PRMT5在恶性肿瘤中的表达及其作用机制  

Expression and mechanism of PRMT5 in malignant cancer

作　　者：沈昊[1] 张玲[2] 刘修恒[1] SHEN Hao;ZHANG Ling;LIU Xiu-heng(Department of Urology,Renmin Hospital of Wuhan University,Wuhan Hubei,430060,China;Department of Pathology,Jingzhou Central Hospital,Jingshou Hubei,434020,China)

机构地区：[1]武汉大学人民医院泌尿外科,湖北武汉430060 [2]荆州市中心医院病理科,湖北荆州434020

出　　处：《职业与健康》2020年第3期418-423,427,共7页Occupation and Health

基　　金：湖北省卫生计生科研基金重点支撑项目(WJ2017Z005);湖北省卫生计生科研基金项目(WJ2018H209).

摘　　要：蛋白质精氨酸甲基转移酶(PRMTs)在蛋白质的甲基化修饰过程中起重要作用。PRMT5是主要的II型精氨酸甲基转移酶,催化两个甲基对称地转移到组蛋白或非组蛋白的精氨酸残基上。近年来,越来越多的研究表明,PRMT5作为一种癌基因,在多种恶性肿瘤中高表达,通过促进癌细胞的增殖、侵袭和迁移,在人类多种肿瘤的发生发展过程中发挥着重要的调控作用,提示PRMT5可能成为肿瘤潜在的生物标志物或治疗靶点。本文综述了PRMT5在肿瘤发生中的生物学作用、机制及临床意义,旨在为今后治疗PRMT5相关疾病提供有效的建议和支撑。Protein arginine methyltransferases(PRMTs) play important roles in protein methylation. PRMT5 is the major type Ⅱarginine methyltransferase that catalyzes the transfer of two methyl groups symmetrically to the arginine residues of either histone or non-histone proteins. In recent years, increasing evidence has shown that PRMT5, as an oncogene, plays an indispensable regulatory role in the pathological progression of several human cancers by promoting the proliferation, invasion and migration of cancer cells. PRMT5 is overexpressed in many malignant tumors and plays an important role in the occurrence and development of cancer, which suggests that PRMT5 may become a potential biomarker or therapeutic target of cancer. This article reviews the biological function, mechanism, and clinical significance of PRMT5 in tumorigenesis, so as to provide effective suggestions and support for the treatment of PRMT5 related diseases in the future.

关 键 词：蛋白质精氨酸甲基转移酶 肿瘤 致癌基因 机制 生物标志物 

分 类 号：R181.32[医药卫生—流行病学]