长链非编码RNA在垂体腺瘤中的研究进展  

Progress of long non-coding RNA in pituitary adenoma

作　　者：丁金科 李承龙 王恒禄 李泽福[1] Ding Jinke;Li Chenglong;Wang Henglu;Li Zefu(Department of Neurosurgery,Binzhou Medical University Hospital,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院神经外科,山东滨州256600

出　　处：《肿瘤研究与临床》2020年第1期69-72,共4页Cancer Research and Clinic

基　　金：国家自然科学基金(81171119);山东省自然科学基金(ZR2018LH007)。

摘　　要：垂体腺瘤是一种常见的神经内分泌肿瘤,复杂的发病机制使其治疗成为临床难题。近来有研究表明长链非编码RNA(LncRNA)作为一类长度超过200个核苷酸且基本无蛋白质编码功能的内源性RNA,以各种形式在包括垂体腺瘤在内的多种肿瘤中发挥着重要的调控作用,且与垂体腺瘤的增殖、侵袭及转移等关系密切。文章结合国内外最新研究现状,对LncRNA在垂体腺瘤中的研究进展进行综述,以期为垂体腺瘤的诊断、治疗及预后提供新的思路。Pituitary adenoma is a common neuroendocrine tumor,and its complex pathogenesis makes its treatment a clinical problem.Recently,studies have shown that long non-coding RNA(LncRNA),as a class of endogenous RNA with a length of more than 200 nucleotides and basically no protein-coding function,plays an important regulatory role in various forms in multiple tumors including pituitary adenoma,and is closely related to the proliferation,invasion and metastasis of pituitary adenoma.Based on the latest research status at home and abroad,this paper summarizes the research progress of LncRNA in pituitary adenoma,hoping to provide new ideas for the diagnosis,treatment and prognosis of pituitary adenoma.

关 键 词：神经内分泌瘤 脑肿瘤 长链非编码RNA 

分 类 号：R73[医药卫生—肿瘤]