外泌体非编码RNA作为结核病诊断潜在生物标志物的研究进展  

Research progress of exosomal non-coding RNA as potential biomarkers of tuberculosis

作　　者：高书慧 赵俊伟[1] GAO Shu-hui;ZHAO Junwei(Department of Laboratory Medicine,the First Affiliated Hospital of Zhengzhou University,Key Clinical Laboratory of Henan Province,Zhengzhou 450052 China)

机构地区：[1]郑州大学第一附属医院检验科河南省检验医学重点实验室,450052

出　　处：《中国防痨杂志》2020年第3期282-285,共4页Chinese Journal of Antituberculosis

基　　金：国家自然科学基金(81501715)

摘　　要：结核病仍然是严重危害人类健康的慢性传染性疾病,外泌体在结核病的发生发展中扮演了重要角色.非编码RNA与结核病的诊断近年也备受关注。作者阐述了外泌体与结核分枝杆菌感染、外泌体非编码RNA与结核病诊断的最新进展.旨在从外泌体非编码RNA的角度为结核病早期诊断、疗效监测、预后判断的研究提供新的思路。Tuberculosis is still a chronic infectious disease which is seriously harmful to human health.Exosome plays an important role in the occurrence and development of tuberculosis.Recently,more and more attention has been paid to the role of non-coding RNA in tuberculosis diagnosis.In this paper,the latest developments of exosome and Mycobacterium tuberculosis infection,exosomal non-coding RNA and tuberculosis diagnosis are reviewed.in order to provide a new idea for the study of early diagnosis,efficacy monitoring and prognosis estimation of tuberculosis from the perspective of exosomal non-coding RNA.

关 键 词：结核 外泌体 RNA探针 生物学标记 综述 

分 类 号：R52[医药卫生—内科学]