婴儿胆固醇和糖化血红蛋白浓度的影响因素分析  

Analysis of influence factors of cholesterol and glycosylated hemoglobin concentration in infant

作　　者：戴方娣 李艳华 高丽娟[2] DAI Fang-di;LI Yan-hua;GAO Li-juan(Department of Pediatrics,Zhoushan Maternal and Child Health Hospital,Zhoushan,Zhejiang 316000,China)

机构地区：[1]舟山市妇幼保健院儿科,浙江舟山316000 [2]丽水市中心医院儿科,浙江丽水323000

出　　处：《中华全科医学》2020年第4期597-600,共4页Chinese Journal of General Practice

基　　金：浙江省医药卫生科技计划项目(2016KYA202)。

摘　　要：目的探究婴儿胆固醇和糖化血红蛋白浓度和母体因素及婴儿饮食因素的相关性。方法选取2016年1月-2019年1月于舟山市妇幼保健院门诊就诊的患儿524例。根据标准,最终纳入143例,其中出生6个月的婴儿84例,出生12个月的婴儿59例。对患儿与母亲进行饮食调查,并采取静脉血检测总胆固醇(TC)、糖化血红蛋白(HbA1c)水平,利用单因素和多因素回归对婴儿TC和HbA1c的影响因素进行分析。结果婴儿TC水平为2.3~6.6 mmol/L,平均浓度为(4.1±0.8)mmol/L,经过Spearman相关性分析显示,母亲TC水平和婴儿膳食蛋白质占比与婴儿TC呈正相关性(r分别为0.391和0.279,均P<0.05),多因素回归校正后母亲TC水平和婴儿膳食蛋白质占比与婴儿TC具有独立相关性(均P<0.05)。婴儿HbA1c水平为3.7~6.0 mmol/L,平均浓度为(4.9±0.4)mmol/L,经过单因素和多因素回归分析,暂未发现母体因素和膳食与婴儿HbA1c存在相关性(P>0.05)。结论母亲TC水平和婴儿膳食蛋白质占比会影响婴儿TC水平,因此需要控制母亲TC水平及婴儿膳食蛋白质合理占比,降低婴儿高TC血症发生情况。Objective To explore the correlation of infant cholesterol and glycosylated hemoglobin concentration with maternal factors and infant dietary factors. Methods A total of 524 children from January 2016 to January 2019 were selected from the outpatient clinic of Zhoushan Maternal and Child Health Hospital. According to the criteria, 143 cases were eventually included, of which 84 were born 6 months and 59 were born 12 months. Dietary survey was conducted between the infants and their mothers, and the levels of total cholesterol(TC) and glycosylated hemoglobin(HbA1 c) were measured by intravenous blood. The influence factors of TC and HbA1 c in infants were analyzed by multivariate regression. Results The TC level of infants varied from 2.3 to 6.6 mmol/L with an average concentration of(4.1±0.8) mmol/L. Spearman correlation analysis showed that maternal TC level and dietary protein of infants were positively correlated with TC level of infants(r=0.391, 0.279, all P<0.05). After multivariate regression, maternal TC level and dietary protein of infants were independently correlated with TC of infants(P<0.05). The level of HbA1 c in infants ranged from 3.7 to 6.0 mmol/L with an average concentration of(4.9±0.4) mmol/L. There was no correlation between maternal factors, diet and HbA1 c of infant(P>0.05) by univariate and multivariate regression analysis. Conclusion Maternal TC level and infant dietary protein ratio can affect infant TC level, so it is necessary to control maternal TC level and infant dietary protein ratio to reduce the incidence of infant TC.

关 键 词：婴儿 胆固醇 糖化血红蛋白 母体因素 饮食 

分 类 号：R174[医药卫生—妇幼卫生保健] R446[医药卫生—公共卫生与预防医学]