复发性流产患者多次自然流产高危因素分析  

Analysis of high risk factors of multiple spontaneous abortion in patients with recurrent spontaneous abortion

作　　者：穆鑫 张娜[1] 朱峰[2] 师娟子 MU Xin;ZHANG Na;ZHU Feng;SHI Juan-zi(Reproductive Center,Northwest Women's and Children's Hospital,the Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061;Translational Medicine Center,First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学附属西北妇女儿童医院生殖中心,陕西西安710061 [2]西安交通大学第一附属医院转化医学中心,陕西西安710061

出　　处：《临床医学研究与实践》2020年第7期15-18,共4页Clinical Research and Practice

摘　　要：目的分析复发性流产(RSA)患者多次自然流产的高危因素。方法回顾性分析2017年1月至2018年12月我院收治的1037例RSA患者的临床资料,根据既往自然流产次数分为流产2次组(n=787)及流产≥3次组(n=250)。比较两组患者的一般资料及临床检查指标,分析RSA患者多次自然流产的危险因素。结果流产≥3次组的女方年龄、男方年龄、女方BMI均高于流产2次组(P<0.05)。流产≥3次组的男方染色体异常发生率低于流产2次组,Tg-Ab异常发生率高于流产2次组(P<0.05)。多因素Logistic回归分析结果显示,女方年龄、Tg-Ab、HCY为多次流产发生的独立危险因素(P<0.05)。结论2次流产患者应重视筛查血清HCY及甲状腺自身抗体,如发现异常,立即给予对症处理;在各项指标达标的情况下,应尽早妊娠,以降低因高龄而引起的再次流产。Objective To analyze the high risk factors of multiple spontaneous abortion in patients with recurrent spontaneous abortion(RSA). Methods The clinical data of 1 037 patients with RSA admitted in our hospital from January 2017 to December 2018 were analyzed retrospectively, and the patients were divided into abortion twice group(n=787) and abortion≥3 times group(n=250) according to the number of previous spontaneous abortions. The general data and clinical examination indexes of the two groups were compared, and the risk factors of multiple spontaneous abortion in RSA patients were analyzed.Results The age of female, age of male and BMI of female in the abortion ≥3 times group were higher than those in the abortion twice group(P<0.05). The incidence of male chromosomal abnormality in the abortion ≥3 times group was lower than that in the abortion twice group, and the incidence of Tg-Ab abnormality was higher than that in the abortion twice group(P<0.05). The multivariate Logistic regression analysis showed that the age of female, Tg-Ab and HCY were independent risk factors for multiple abortions(P<0.05). Conclusion The patients with two abortions should pay attention to the screening of serum HCY and thyroid autoantibody, if any abnormality is found, it shall be treated immediately;in the case of reaching the standards of various indicators, pregnancy should be carried out as early as possible to reduce the re-abortion caused by advanced age.

关 键 词：复发性流产 多次自然流产 高危因素 

分 类 号：R714.21[医药卫生—妇产科学]