TiO2纳米管负载米诺环素的释放动力学研究  

The study on release kinetics of minocycline loaded on the TiO2 nanotubes in vitro

作　　者：程佳蕙 吴雨峰 王泽华 高啟坤 吴明月[2,3] Cheng Jiahui;Wu Yufeng;Wang Zehua(Stomatologic Hospital of Anhui Medical University;Affliated Stomatological Hospital of Anhui Medical University, Hefei 230032)

机构地区：[1]安徽医科大学口腔医学院,合肥230032 [2]安徽医科大学附属口腔医院,合肥230032 [3]安徽省口腔疾病研究中心实验室,合肥230032

出　　处：《安徽医科大学学报》2020年第2期210-214,共5页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81170993)。

摘　　要：目的研究不同管径TiO2纳米管(TNT)形貌对米诺环素负载的影响,探索其缓释效果。方法采用阳极氧化法以10、20、30 V电压分别在钛表面制备不同管径的TiO2纳米管,并在表面加载盐酸米诺环素(MH),构建抗菌涂层。通过场发射扫描电镜、接触角测量仪、X射线光电子能谱仪、傅里叶红外光谱以及紫外分光光度计对样品进行表征,比较其缓释效果。结果10、20、30 V电压可制备管径约30、70、120 nm的TiO2纳米管涂层,70 nm TiO2纳米管组载药量最高、缓释效果最佳,其次为120 nm TiO2纳米管组、30 nm TiO2纳米管组。结论70 nm管径的TiO2纳米管的载药量最高、缓释效果最好,有望提高钛种植体表面的持续抗菌性能。Objective To study the effect of TiO2 nanotubes(TNT)with differe-nt diameters on the loading of minocycline and explore its sustained release e-ffect.Methods TNT with different diameters were fabricated on the surface of titanium by anodizing at 10,20 and 30V,and minocycline hydrochloride(MH)was loaded on the surface to construct an antibacterial coating.The samples were characterized by electron microscopy,contact angle measurement,X-ray diffraction,Fourier transform infrared spectroscopy and UV-Visible spectrophotometer,to compare the sustained release effects.Results Anodization at 10,20 and 30V voltage produced 30,70 and 120 nm nanotube coating.The 70 nm TNT had the highest drug loading and the best sustained release effect,followed by 120nm TNT and 30 nm TNT.Conclusion The 70 nm TNT has the highest drug loading and the best sustained release effect,which is expected to improve sustained antibacterial properties of the titanium implant surface.

关 键 词：TIO2纳米管 盐酸米诺环素 缓释 种植体周围炎 

分 类 号：R318.08[医药卫生—生物医学工程]