辅助生殖夫妇术前抑郁情绪的影响因素及其对活产率的影响  

Factors associated with the depression of couples preparing for assisted reproductive and their effect on live birth rate

作　　者：时梦醒 王康霞 鲁智敏 曹云霞[2] 孟秀红[1,3] Shi Mengxing;Wang Kangxia;Lu Zhimin(Dept of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032;Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University, Hefei 230022)

机构地区：[1]安徽医科大学公共卫生学院儿少卫生与妇幼保健学系,合肥230032 [2]安徽医科大学第一附属医院生殖医学中心,合肥230022 [3]人口健康与优生安徽重点实验室,合肥230032

出　　处：《安徽医科大学学报》2020年第2期272-276,共5页Acta Universitatis Medicinalis Anhui

基　　金：国家重点研发计划“生殖健康及重大出生缺陷防控研究”重点专项(编号:2016YFC1000204-3);国家自然科学基金(编号:81773442)。

摘　　要：目的研究辅助生殖夫妇术前抑郁情绪的影响因素,及其对活产率的影响。方法以中国国家出生队列为平台,采用流调用抑郁自评量表(CES-D)对进行体外受精-胚胎移植(IVF-ET)或卵胞浆内单精子注射(ICSI)治疗的夫妻进行抑郁情绪自评调查,随访活产率。结果共纳入424对辅助生殖夫妇,结果显示,在女性患者中33.0%存在抑郁情绪,男性患者中25.9%存在抑郁情绪。文化程度是女性患者出现抑郁情绪的影响因素,文化程度高的女性患者比文化程度低者更易出现抑郁情绪,差异有统计学意义(P<0.05)。不饮酒的男性患者更容易出现抑郁情绪(P<0.05)。Logistic回归分析未提示男女双方抑郁情绪对活产率有不良影响。结论文化程度高是女性患者出现情绪问题的危险因素。不饮酒的男性患者更容易出现抑郁情绪。该研究未提示辅助生殖夫妇抑郁情绪对活产率有不良影响,后续的研究应注重减轻不孕治疗的困扰。Objective To investigate the factors related to the depression of couples preparing for assisted reproduction,and to evaluate whether depression is related to the live birth rate.Methods Based on China National Birth Cohort,the center for epidemiological survey(CES-D)was used to evaluate depression among the couples undergoing in vitro fertilization and embryo transfer(IVF-ET)or intracytoplasmic sperm injection(ICSI),and live birth rate were calculated.Results A total of 424 undergoing assisted reproductive couples were enrolled in this study.There were 33.0%of the female patients with depression,and 25.9%of the male cases with depression.Education level was the influencing factor of depression in female patients.Female patients with high education level were more likely to have depression than those with low education level,and the difference was statistically significant(P<0.05).Male patients who do not drink alcohol were more likely to be depression(P<0.05).The result of logistic regression analysis showed that the depression of couples undergoing assisted reproduction was not related to live birth rate.Conclusion Higher education is a risk factor for depression of female patients.Male patients who do not drink are more prone to depression.This study does not suggest that depression of assisted reproductive couples had any influence on the live birth rate.Follow-up studies should focus on alleviating the problem of infertility treatment.

关 键 词：辅助生殖 抑郁 出生队列 活产率 

分 类 号：R711.6[医药卫生—妇产科学]