18F-脱氧葡萄糖PET/CT代谢参数与结直肠癌临床特征及血清CEA、CA199、VEGF的相关性研究  

Correlation between 18F-deoxyglucose PET/CT metabolic parameters and clinical features of colorectal cancer and serum CEA,CA199 and VEGF

作　　者：王泉 徐慧琴[1] 汪会[1] 余文静 张丹[1] Wang Quan;Xu Huiqin;Wang Hui(Dept of Nuclear Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022)

机构地区：[1]安徽医科大学第一附属医院核医学科,合肥230022

出　　处：《安徽医科大学学报》2020年第2期277-281,共5页Acta Universitatis Medicinalis Anhui

基　　金：安徽省科技攻关计划项目(编号:1704a0802164)。

摘　　要：目的探讨18F-脱氧葡萄糖(FDG)PET/CT代谢参数与结直肠癌(CRC)临床特征及肿瘤标志物的相关性。方法回顾性分析76例CRC患者的临床资料及术前PET/CT资料,检测原发灶的最大标准摄取值(SUVmax)、平均标准摄取值(SUVmean)及代谢体积(MTV),并计算得到糖酵解总量(TLG),分析上述代谢参数与临床病理特征及肿瘤标志物的相关性。结果CRC原发灶SUVmax、SUVmean、MTV、TLG分别为13.15(9.10,16.40)、7.50(5.20,9.70)、16.30(9.32,24.10)cm3、114.75(61.45,201.12)g。原发灶MTV及TLG与病灶沿肠长度呈正相关(ρ=0.773、0.704,P<0.05),而SUVmax及SUVmean与病灶沿肠长度无相关性(P>0.05);SUVmax、SUVmean、MTV及TLG均与分化程度呈正相关(ρ=0.258、0.235、0.238、0.295,P<0.05);SUVmax及SUVmean与Kras基因突变呈正相关(ρ=0.321、0.317,P<0.05),而MTV及TLG与Kras基因突变无相关性(P>0.05);SUVmax、SUVmean、MTV及TLG均与T分期呈正相关(ρ=0.274、0.256、0.444、0.541,P<0.05);仅MTV与N分期呈正相关(ρ=0.290,P<0.05),SUVmax、SUVmean及TLG与N分期无相关性(P>0.05);MTV及TLG与血清血管内皮生长因子(VEGF)呈正相关(ρ=0.250、0.288,P<0.05),SUVmax及SUVmean与血清VEGF无相关性(P>0.05),各代谢参数与性别、年龄、M分期、癌胚抗原(CEA)、糖类抗原199(CA199)均无相关性(P>0.05)。结论CRC原发灶代谢参数与部分临床特征及血清肿瘤标志物具有一定的相关性。Objective To investigate the correlation between metabolic parameters of 18F-fluorodeoxyglucose(FDG)PET/CT and clinical features and tumor markers of colorectal cancer(CRC).Methods The clinical data and preoperative PET/CT data of 76 patients with CRC were retrospectively analyzed.Maximum standardized uptake value(SUVmax),mean standardized uptake value(SUVmean)and metabolic tumor value(MTV)of primary lesion were measured,and total lesion glycolysis(TLG)was calculated.Relationship between metabolic parameters and clinicopathological features and tumor markers was analyzed.Results SUVmax,SUVmean,MTV and TLG of 76 primary lesions were 13.15(9.10,16.40),7.50(5.20,9.70),16.30(9.32,24.10)cm3 and 114.75(61.45,201.12)g,respectively.MTV and TLG of primary lesion were positively associated with the length of lesion along the intestine(ρ=0.773,0.704,P<0.05),while SUVmax and SUVmean were not significantly associated with length of lesion along the intestine(P>0.05);SUVmax,SUVmean,MTV and TLG were all positively associated with the degree of differentiation(ρ=0.258,0.235,0.238,0.295,P<0.05);SUVmax and SUVmean were positively associated with Kras gene mutation(ρ=0.321,0.317,P<0.05),but MTV and TLG were not significantly associated with Kras gene mutations(P>0.05);SUVmax,SUVmean,MTV and TLG were all positively associated with T stage(ρ=0.274,0.256,0.444,0.541,P<0.05).Only MTV was positively correlated with N stage(ρ=0.290,P<0.05),SUVmax,SUVmean and TLG had no significant correlation with N stage(P>0.05);MTV and TLG were positively associated with vascular endothelial growth factor(VEGF)(ρ=0.250,0.288,P<0.05),SUVmax and SUVmean were not significantly associated with VEGF(P>0.05).None of the parameters had correlation with gender,age,M stage,carcinoembryonic antigen(CEA)and carbohydrate antigen199(CA199)(P>0.05).Conclusion Metabolic parameters of CRC primary lesion have certain correlation with some clinical features and serum tumor markers.

关 键 词：结直肠癌 正电子发射计算机断层显像 Kras基因突变 代谢参数 

分 类 号：R817.4[医药卫生—影像医学与核医学]