阿法骨化醇预防早产儿佝偻病疗效分析  

Effect of Alfacalcitol on Prevention of Rickets in Premature Infants

作　　者：任文娟[1] 张桂玲[1] 杨雅丽 赵会娟[1] 李树军[1] 方庆娟 REN Wen-juan;ZHANG Gui-ling;YANG Ya-li;ZHAO Hui-juan;LI Shu-jun;FANG Qing-juan(Department of Pediatrics,The 81st Hospital of PLA,Zhangjiakou,Hebei 075000,China;Neonatal Department,Maternal and Child Health Hospital of Zhangjiakou City,Zhangjiakou,Hebei 075000,China;Department of Respiratory and Critical Care Medicine,No.1 Hospital of Zhangjiakou City,Zhangjiakou,Hebei 075000,China)

机构地区：[1]中国人民解放军陆军第八十一集团军医院儿科,河北张家口075000 [2]河北省张家口市妇幼保健院新生儿科,河北张家口075000 [3]河北省张家口市第一医院呼吸与危重症医学二科,河北张家口075000

出　　处：《河北北方学院学报（自然科学版）》2020年第4期15-17,20,共4页Journal of Hebei North University:Natural Science Edition

基　　金：张家口市科学技术研究与发展计划项目(No.1921110D)。

摘　　要：目的探讨阿法骨化醇在预防早产儿佝偻病中的干预作用。方法选取早产儿168名,胎龄35~37周,利用随机数表法分成实验组和对照组各84例。实验组用阿法骨化醇治疗,对照组用维生素D滴剂治疗。对比2组佝偻病发生率、血钙、25-羟基维生素D 3及骨源性碱性磷酸酶水平。结果实验组佝偻病发生率(2.38%)低于对照组(16.67%)(P<0.05)。实验组治疗30 d后血钙水平、25-羟基维生素D 3水平、骨源性碱性磷酸酶水平优于对照组[(2.48±0.17)mmol·L^-1 vs(2.25±0.13)mmol·L^-1、(56.15±6.28)ng·mL^-1 vs(33.53±7.30)ng·mL^-1、(121.53±16.02)U·L^-1 vs(188.71±18.02)U·L^-1](P<0.05)。结论合理使用阿法骨化醇可有效预防早产儿佝偻病的发生,且有助于改善早产儿血钙等指标,值得临床推广应用。Objective To study the effect of alfacalcitol on the prevention of rickets in premature infants.Methods From August 2017 to July 2019 in our hospital,168 preterm infants aged from 35 w to 37 w were divided into experimental group and control group(n=84)by random number table method.Alfacalcitol was used in the experimental group and vitamin D 3 in the control group.The incidence of rickets and the levels of blood calcium,bone alkaline phosphatase,25-hydroxyvitamin D 3 were respectively compared between the two groups.Results The incidence of rickets in the experimental group was 2.38%,lower than that in the control group(16.67%)(P<0.05).The levels of blood calcium(2.48±0.17)mmol/L,25-hydroxyvitamin D 3(56.15±6.28)ng/ml,bone alkaline phosphatase(121.53±16.02)U/L in the experimental group were higher than those in the control group(2.25±0.13)mmol/L,(33.53±7.30)ng/ml,(188.71±18.02)U/L,P<0.05.Conclusion The reasonable use of alfacalcitol can effectively prevent the occurrence of rickets in preterm infants,and contribute to improve the levels of blood calcium and bone alkaline phosphatase,et al.It is recommended to use for rickets in premature infants.

关 键 词：佝偻病 阿法骨化醇 预防 早产儿 25-羟基维生素D 

分 类 号：R722[医药卫生—儿科]