硝苯地平联合福辛普利治疗老年冠心病并高血压疗效及对血小板膜糖蛋白和D-二聚体水平的影响  

The therapeutic efficacy of nifedipine and fosinopril in coronary heart disease complicated with hypertension in the elderly and their impacts on platelet membrane glycoprotein and D-dimer levels

作　　者：林秋伟[1] 魏芝宝[1] 姚超永[1] LIN Qiuwei;WEI Zhibao;YAO Chaoyong(Department of Cardiology,the People’s Hospital of Gaozhou in Guangdong Province,Gaozhou525200,China)

机构地区：[1]广东省高州市人民医院心内科,广东高州525200

出　　处：《中国现代医生》2020年第6期42-44,共3页China Modern Doctor

摘　　要：目的探讨在老年冠心病并发高血压患者的实际治疗当中,将硝苯地平与福辛普利进行联合应用的情况。方法选择我院2016年1月~2018年8月收治的98例老年冠心病并发高血压患者为对象,将其按照随机数字表法均分成对照组与实验组,给予对照组常规硝苯地平单一治疗,而实验组患者则在对照组治疗基础上同时接受福辛普利治疗,观察两组患者的治疗效果、治疗后血压水平与D-二聚体水平,治疗后血小板膜糖蛋白指标以及出现的不良反应情况。结果实验组患者接受治疗后的效果明显好于对照组,治疗后的血压水平、D-二聚体水平等各项指标均优于对照组,数据分析后差异有统计学意义(P<0.05),但是两组患者接受治疗后的不良反应情况均较少,差异无统计学意义(P>0.05)。结论在同时患有冠心病与高血压的老年患者治疗用药选择方面,让其接受硝苯地平与福辛普利联合治疗的效果较好,该方案值得推广。Objective To investigate the therapeutic efficacy of nifedipine combined with fosinopril in coronary heart disease(CHD)complicated with hypertension in the elderly in clinical practices.Methods Ninety-eight old patients with CHD complicated with hypertension who were admitted in our hospital from January 2016 to August 2018 were selected as subjects.They were divided into the control group and the research group using a random number table.Patients in the control group only received nifedipine,and those in the research group additionally and simultaneously accepted fosinopril.Therapeutic effects,blood pressure,D-dimer levels,platelet membrane glycoprotein(GP)levels and the incidence of adverse reaction in the two groups after treatment were observed.Results The research group showed better therapeutic effects than the control group,with better performances in all indices,such as post-treatment blood pressure and D-dimer levels.There were significant differences in these indices between the two groups(P<0.05).The incidence of adverse reaction was low in the two groups with a no significant difference between them(P>0.05).Conclusion Allowing for the fact that these CHD old patients were complicated with hypertension,the judicious drug combination was nifedipine and fosinopril.As the strategy has achieved favorable therapeutic effects,it is worth promoting in clinic.

关 键 词：高血压 老年冠心病 福辛普利 硝苯地平 D-二聚体 

分 类 号：R544.1[医药卫生—心血管疾病] R541.4[医药卫生—内科学]