血清白细胞介素-17和白细胞介素-23在狼疮性肾炎预测中的应用  

Application of serum interleukin-17 and interleukin-23 in the prediction of lupus nephritis

作　　者：叶雅丽[1] 赵肖丽[1] 任应鹏[1] YE Yali;ZHAO Xiaoli;REN Yingpeng(Clinical Laboratory,Taizhou First People's Hospital in Zhejiang Province,Taizhou318020,China)

机构地区：[1]浙江省台州市第一人民医院检验科,浙江台州318020

出　　处：《中国现代医生》2020年第6期158-161,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划项目(2017KY712)。

摘　　要：目的探讨血清白细胞介素-17和白细胞介素-23在狼疮性肾炎预测中的应用。方法对2016年8月~2018年8月我院狼疮性肾炎患者120例及健康体检者60例的临床资料进行回顾性分析,分为三组,统计分析三组人员的一般资料、血清IL-17、IL-23水平及活动组患者治疗前后的血清IL-17、IL-23水平。结果活动组患者的SLEDAI评分、24 h尿蛋白、AI、CI均显著高于稳定组(P<0.05),病理类型Ⅱ型、Ⅲ型比例均显著低于稳定组(P<0.05),Ⅳ型比例显著高于稳定组(P<0.05),活动组、稳定组、对照组的Scr水平逐渐降低(P<0.05),白蛋白、C3、C4水平逐渐升高(P<0.05)。活动组患者的血清IL-17水平显著高于稳定组、对照组(P<0.05);活动组患者的血清IL-23水平显著高于稳定组、对照组(P<0.05),稳定组患者的血清IL-23水平又显著高于对照组(P<0.05)。活动组患者治疗后的血清IL-17、IL-23水平均显著低于治疗前(P<0.05);完全缓解患者的血清IL-23水平显著低于部分缓解、未缓解患者(P<0.05),部分缓解患者的血清IL-23水平又显著低于未缓解患者(P<0.05)。结论血清白细胞介素-17和白细胞介素-23在狼疮性肾炎预测中的应用价值高。Objective To investigate the application of serum interleukin-17 and interleukin-23 in the prediction of lupus nephritis.Methods A retrospective analysis was performed on the clinical data of 120 patients and 60 healthy examiners with lupus nephritis in our hospital from August 2016 to August 2018.The patients were divided into three groups.The general data,and serum IL-17,IL-23 levels of the three groups,and serum IL-17 and IL-23 levels in the active group before and after treatment were statistically analyzed.Results SLEDAI score,24h urine protein,AI and CI were significantly higher in the active group than in the stable group(P<0.05).The proportion of pathological typeⅡand typeⅢwere significantly lower than those in the stable group(P<0.05),and the proportion of typeⅣwas significantly higher than that in the stable group(P<0.05).The levels of Scr in the active,stable and control group were gradually decreased(P<0.05),and the levels of albumin,C3 and C4 were gradually increased(P<0.05).The serum IL-17 level in the active group was significantly higher than that in the stable group and the control group(P<0.05);the serum IL-23 level in the active group was significantly higher than that in the stable group and the control group(P<0.05);the serum IL-23 level in the stable group was significantly higher than that in the control group(P<0.05).The levels of serum IL-17 and IL-23 after treatment in the active group were significantly lower than those before treatment(P<0.05).Serum IL-23 levels in patients with complete remission were significantly lower than those in patients with partial remission and no remission(P<0.05).Serum IL-23 levels were significantly lower in patients with partial remission than those without remission(P<0.05).Conclusion Serum interleukin-17 and interleukin-23 have a high application value in the prediction of lupus nephritis.

关 键 词：血清白细胞介素-17 白细胞介素-23 狼疮性肾炎 预测 

分 类 号：R593.242[医药卫生—内科学]