哮喘宁颗粒对哮喘慢性持续期患者的临床疗效分析  

Clinical effect of xiaochuanning granule on chronic persistent bronchial asthma based on Th1/Th2 immuno-balance

作　　者：曹红艳[1] 喻海忠[1] 袁建芬[1] 郭春燕[1] 唐艳芬[2] Hong-yan Cao;Hai-zhong Yu;Jian-fen Yuan;Chun-yan Guo;Yan-fen Tang(Department of Laboratory,Nantong Hospital of Traditional Chinese Medicine,Nantong,Jiangsu 226001,China;Department of Respiratory Medicine,Nantong Hospital of Traditional Chinese Medicine,Nantong,Jiangsu 226001,China)

机构地区：[1]南通市中医院检验科,江苏南通226001 [2]南通市中医院呼吸内科,江苏南通226001

出　　处：《中国现代医学杂志》2020年第8期45-49,共5页China Journal of Modern Medicine

摘　　要：目的基于Th1/Th2免疫失衡机制观察哮喘宁颗粒对哮喘慢性持续期患者的临床疗效。方法选取2018年1月—2019年2月南通市中医院慢性持续期哮喘患者130例,随机分为对照组(雾化吸入沙美特罗替卡松)和观察组(雾化吸入沙美特罗替卡松+口服哮喘宁颗粒),每组65例。比较两组临床疗效;辅助性T淋巴细胞1(Th1)/Th2分化水平、白细胞介素-4(IL-4)、IL-12、IL-17、干扰素-γ(IFN-γ)等相关炎症因子;T盒子转录因子(T-bet)、GATA结合蛋白3(GATA-3)、维A酸相关孤独受体亚家族γt(RORγt)及叉头框转录因子P3(FoxP3)水平的变化。结果观察组治愈率高于对照组(32.31%VS 13.85%)(P<0.05)。观察组Th2/CD4+、IL-4、IL-17、GATA-3、RORγt降低的差值,以及Th1/CD4+、Th1/Th2比值、IL-12、IFN-γ、T-bet、FoxP3升高的差值均高于对照组(P<0.05)。结论哮喘宁颗粒通过诱导Th0细胞向Th1型细胞分化,抑制Th2型细胞分化能力,提高Th1/Th2比值,进而提高慢性持续期哮喘患者的治愈率。Objective To compare the clinical effect of xiaochuanning granule on chronic persistent bronchial asthma based on Th1/Th2 immuno-balance.Methods From January 2018 to February 2019,130 patients with chronic persistent bronchial asthma in our hospital were collected and randomly divided into control group(salmeterol and fluticasone propionate inhalation)and observation group(salmeterol and fluticasone propionate inhalation+xiaochuanning granule).The clinical effect was observed.The changes of Th1/CD4+,Th2/CD4+,Th1/Th2,related cytokines,such as interleukin(IL)-4,IL-12,IL-17,interferon-γ(IFN-γ),and nuclear transcription factors,such as T-box expressed in T cells(T-bet),GATA-binding protein 3(GATA-3),retinoid related orphan nuclear receptor subfamilyγt(RORγt),fork-head box P3(FoxP3)mRNAs,were compared between the two groups.Results After 12 months of treatment,the recovery rate of observation group were 32.31%(21/65),higher than that of control group(P<0.05).Patients in both groups had lower Th2/CD4+(%),serum values of IL-4,IL-17 and GATA-3 mRNA,RORγt mRNA than before treatment,while they had higher Th1/CD4+(%),Th1/Th2 ratio,the serum values of IL-10,IFN-γand T-bet mRNA,FoxP3 mRNA.The declined differences of Th2/CD4+(%),serum values of IL-4,IL-17 and GATA-3 mRNA,RORγt mRNA and the increased differences of Th1/CD4+(%),Th1/Th2 ratio,the serum values of IL-10,IFN-γand T-bet mRNA,FoxP3 mRNA in observation group were higher than those in control group(P<0.05).Conclusion The application of xiaochuanning granule in the treatment of chronic persistent bronchial asthma could effectively improve the clinical recovery by regulating Th1/Th2 immuno-balance,which would be recommended for an effective treatment.

关 键 词：哮喘宁颗粒 支气管哮喘 慢性持续期 Th1/Th2免疫平衡 转录因子 

分 类 号：R562.25[医药卫生—呼吸系统]