新生儿缺氧缺血性脑病血清高迁移率族蛋白B1水平及与炎症反应和神经损伤的相关性  

Serum high mobility group box-1 protein level in neonatal hypoxic ischemic encephalopathy and its relationship with inflammatory response and nerve injury

作　　者：王洪蓉 汤晶晶[2] Hong-rong Wang;Jing-jing Tang(Department of Pediatrics,Ningbo Yinzhou People’s Hospital,Ningbo,Zhejiang 315000,China;Department of Pediatrics,Affiliated Hospital of Ningbo University Medical School,Ningbo,Zhejiang 315020,China)

机构地区：[1]宁波市鄞州人民医院儿科,浙江宁波315000 [2]宁波大学医学院附属医院儿科,浙江宁波315020

出　　处：《中国现代医学杂志》2020年第8期119-123,共5页China Journal of Modern Medicine

摘　　要：目的研究新生儿缺氧缺血性脑病(HIE)血清高迁移率族蛋白B1(HMGB1)水平及其与炎症因子和神经损伤的关系,探讨HMGB1在HIE中的临床意义。方法选取2008年1月-2018年12月宁波市鄞州人民医院和宁波大学医学院附属医院儿科收治的HIE新生儿120例作为HIE组,同期该院健康新生儿120例作为对照组。HIE新生儿根据严重程度分为轻度61例,中度39例,重度20例。测定血清HMGB1、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、神经元特异性烯醇化酶(NSE)、S100B水平。结果 HIE组血清HMGB1、IL-6、TNF-α、NSE、S100B水平高于对照组(P<0.05)。不同严重程度HIE患儿血清HMGB1、IL-6、TNF-α、NSE、S100B水平比较,差异有统计学意义(P <0.05),中度和重度HIE患儿血清HMGB1、IL-6、TNF-α、NSE、S100B水平高于轻度(P<0.05),重度HIE患儿血清HMGB1、IL-6、TNF-α、NSE、S100B水平高于中度(P<0.05)。HIE患儿血清HMGB1与IL-6、TNF-α、NSE、S100B呈正相关(r=0.523、0.602、0.497和0.525,P<0.05)。结论 HIE新生儿血清HMGB1水平升高,血清HMGB1水平与病情严重程度、炎症因子水平和神经损伤关系密切。Objective To investigate the serum high mobility group box 1(HMgB1) level and its relationship with inflammatory factors and nerve damage in neonatal hypoxic ischemic encephalopathy(HiE) in order to explore the clinical significance of HMgB1 in HiE. Methods From January 2008 to december 2018, 120 HiE newborns were selected as HiE group and 120 healthy newborns were selected as control group in the department of Pediatrics of ningbo Yinzhou People’s Hospital and Affiliated Hospital of ningbo university medical school. HiE newborns were classified into mild 61 cases, moderate 39 cases and severe 20 cases accorded to their severity. The serum HMgB1, interleukin-6(iL-6), tumor necrosis factor-α(TnF-α), neuron-specific enolase(nSE) and S100 B levels were measured. Results The levels of serum HMgB1, iL-6, TnF-α, nSE and S100 B in HiE group were higher than those in control group(P < 0.05). The levels of serum HMgB1, iL-6, TnF-α, nSE and S100 B in patients with different severity of HiE were statistically significant(P < 0.05), the levels of serum HMgB1, iL-6, TnF-α, nSE and S100 B in patients with moderate and severe HiE were higher than those of mild patients(P < 0.05), and the serum HMgB1, iL-6, TnF-α, nSE and S100 B levels in patients with severe HiE were higher than those of moderate patients(P < 0.05). The serum HMgB1 in patients with HiE were positively correlated with iL-6(r = 0.523), TnF-α(r = 0.602), nSE(r = 0.497) and S100 B(r = 0.525)(all P < 0.05). Conclusion The serum HMgB1 level is elevated in HiE neonates, and serum HMgB1 level is closely related to severity of disease, inflammatory factor levels and nerve damage.

关 键 词：缺氧缺血性脑病/缺氧缺血 脑 新生儿学 HMGB1蛋白 白细胞介素6 肿瘤坏死因子α 神经元特异性烯醇化酶/磷酸丙酮酸水合酶 S100B/蛋白 

分 类 号：R722.1[医药卫生—儿科]