真菌来源的抗微生物多肽研究进展  

Research progress of antimicrobial peptides derived from fungi

作　　者：沈秉正[1,2] 李雪珂 杨海峰 喻研 SHEN Bingzheng;LI Xueke;YANG Haifeng;YU Yan(Department of Pharmacy,Renmin Hospital of Wuhan University,Wuhan 430060,China;State Key Laboratory of Virology,College of Life Sciences,Wuhan University,Wuhan 430072,China;Department of Gastroenterology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]武汉大学人民医院药学部,湖北武汉430060 [2]武汉大学生命科学学院病毒学国家重点实验室,湖北武汉430072 [3]华中科技大学同济医学院附属同济医院消化内科,湖北武汉430060

出　　处：《广东药科大学学报》2020年第2期303-308,F0003,共7页Journal of Guangdong Pharmaceutical University

基　　金：国家自然科学基金青年基金项目(31700086;81900476)。

摘　　要：随着测序技术发展,越来越多真菌的基因组、转录组序列被测定。目前,已有17个真菌来源的抗微生物多肽相继被发现,其氨基酸序列及空间结构呈现出多样性(主要包括线性多肽和含分子内二硫键多肽)。本文从多肽的氨基酸序列、多肽性质、结构特点、抗微生物活性等方面对真菌来源的抗微生物多肽进行综述。With the development of sequencing technology,more and more fungal genomes and transcriptome sequences have been determined.At present,17 fungal-derived antimicrobial polypeptides have been discovered,and their amino acid sequences and spatial structures present diversity,mainly including linear peptides and peptides containing disulfide-bonds.In this paper,the fungi-derived antimicrobial peptides are reviewed in terms of amino acid sequence,properties,structural characteristics and antimicrobial activities.

关 键 词：真菌 抗微生物多肽 活性 结构与功能 

分 类 号：R379[医药卫生—病原生物学]