从肠道菌群角度再认识血管紧张素转换酶2在严重急性呼吸综合征冠状病毒2致病机制中的潜在作用  

Re-understanding the potential mechanism of angiotensin converting enzyme 2 in severe acute respiratory syndrome coronavirus 2 pathogenicity from the perspective of gut microbiota

作　　者：杨浩 邬永琳 荣星喻 严雨晨 汪慧菁 牛辰[1,2] 赵超 YANG Hao;WU Yonglin;RONG Xingyu;YAN Yuchen;WANG Huijing;NIU Chen;ZHAO Chao(MOE/NHC/CAMS Key Laboratory of Molecular Virology,School of Basic Medical Sciences,Shanghai Medical College,Fudan university,Shanghai 200032,China;National Clinical Research Center on Aging and Medicine,Huashan Hospital,Shanghai 200040,China;Laboratory of Neuropsychopharmacology,Shanghai University of Medicine&Health Sciences,Shanghai 201318,China)

机构地区：[1]复旦大学上海医学院基础医学院教育部/卫健委/医科院医学分子病毒学重点实验室,上海200032 [2]国家老年疾病临床医学研究中心(复旦大学附属华山医院),上海200040 [3]上海健康医学院神经精神药理学实验室,上海201318

出　　处：《微生物与感染》2020年第2期104-107,共4页Journal of Microbes and Infections

基　　金：“十三五”国家重点研发计划(2018YFC2000503,2018YFC2000500);复旦大学卓学计划(2015);上海医学院卿枫计划。

摘　　要：2019冠状病毒病(coronavirus disease 2019,COVID-19)的病原学和临床表现多有报道。该病在病原学和临床表现上与发生在2003年的严重急性呼吸综合征(severe acute respiratory syndrome,SARS)有诸多相似性。本文通过对比两者异同,尝试从其共同受体血管紧张素转换酶2(angiotensin converting enzyme 2,ACE2)角度,提出并探讨患者肠道菌群可能参与其致病的潜在机制,旨在为深入探索新型冠状病毒,即严重急性呼吸综合征冠状病毒2(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)的致病机制及加速研发重症肺炎预测指标提供一种可能的新思路。Since the out breaking of coronavirus induced disease 2019(COVID-19),the etiology and clinical manifestations of the disease have been reported and analyzed.There are many similarities between the etiology and clinical manifestations of the SARS in 2003.By comparing the similarities and differences between them,this study attempts to put forward and explore the potential mechanism of gut microbiota in patients,which may participate in its pathogenesis from the perspective of the shared receptor angiotensin converting enzyme 2(ACE2).It may provide a possible way for in-depth study of the pathogenesis of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and the development of prediction indicators for severe pneumonia.

关 键 词：肠道菌群 2019冠状病毒病 严重急性呼吸综合征 血管紧张素转换酶2 

分 类 号：R373.1[医药卫生—病原生物学] R378[医药卫生—基础医学]