意识障碍动物模型制作的研究进展  

Establishment of Animal Models of Disturbance of Consciousness

作　　者：刘倩 孙伟铭[1,2] 冯珍[1,2] LIU Qian;SUN Wei-ming;FEGN Zhen(Department of Rehabilitation,the First Affiliated Hospital,Nanchang University,Nanchang 330006,China;the First Clinical Medical College,Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第一附属医院康复医学科,南昌330006 [2]南昌大学第一临床医学院,南昌330006

出　　处：《南昌大学学报（医学版）》2020年第1期83-87,共5页Journal of Nanchang University：Medical Sciences

基　　金：国家自然科学基金(81860409,81660382);江西省青年科学基金(20171BAB215025);江西省教育厅科技计划项目青年项目(GJJ160268)。

摘　　要：意识障碍类型多样,致病机制复杂,实验研究和临床治疗尤为重要。医学研究常借助于动物模型以突破以人作为实验对象的局限性,为诊断和治疗疾病提供依据。因此,选择合适的动物模型将有助于实验研究的进行。文章综述了国内外常用的意识障碍动物模型的建模方法和模型评价。Experimental research and clinical treatment are particularly important for disturbance of consciousness because of its various types and complex pathogenesis.Animal models are often used in medical research to break through the limitations of using humans as the experimental subjects and provide evidence for the diagnosis and treatment of diseases.Therefore,the selection of appropriate animal models will be helpful for the experimental research.This paper reviews the methods of modeling and evaluation of animal models of conscious disturbance.

关 键 词：意识障碍 脑损伤 动物模型 制作方法 

分 类 号：R332[医药卫生—人体生理学]