纳米载体-近红外光热疗法在肿瘤治疗中的研究进展  

Research Progress of Nanocarrier-Near Infrared Photothermotherapy in Tumor Therapy

作　　者：谭曼曼 刘燕玲[3,4] 张瑜娟 闵卫平[2,4] TAN Man-man;LIU Yan-ling;ZHANG Yu-juan;MIN Wei-ping(Medical Department of Graduated School,Nanchang University,Nanchang 330006,China;Department of Immunology,Basic Medical College,Nanchang University,Nanchang 330006,China;School of Nursing,Jiangxi University of Science and Technology,Nanchang 330098,China;Department of Oncology and Immunology,Jiangxi Academy of Medical Sciences,Nanchang 330006,China)

机构地区：[1]南昌大学研究生院医学部,南昌330006 [2]南昌大学基础医学院免疫教研室,南昌330006 [3]江西科技学院护理学院,南昌330098 [4]江西省医学科学院肿瘤与免疫室,南昌330006

出　　处：《南昌大学学报（医学版）》2020年第1期88-93,共6页Journal of Nanchang University：Medical Sciences

基　　金：国家自然科学基金(81673009);江西省青年科学基金资助项目(20171BAB215082)。

摘　　要：光热疗法(PTT)是一种新颖且快速发展的癌症治疗方法。近红外激光(NIR)有良好组织透过性和非侵入性,是进行光热治疗的理想光源。目前已有多种纳米材料开发成PTT类纳米载体可用于癌症的光热治疗。光热转换纳米材料在生物组织的诊疗中前景广阔,同NO、siRNA、化疗药物等结合后疗效更好。近些年来通过纳米载体进行肿瘤的靶向治疗也引起了广泛的关注,文章对该类方面的应用进行综述。Photothermotherapy(PTT)is a novel and rapidly evolving treatment for cancer.Near infrared(NIR)has good tissue permeability and non-invasiveness,making it an ideal source for PTT.A variety of nanomaterials have been developed into PTT-based nanocarriers for PTT of cancer.Photothermal conversion nanomaterials have broad prospects in the diagnosis and treatment of biological tissues,and are more effective in combination with NO,siRNA and chemotherapy drugs.At the same time,targeted therapy of tumors through nanocarriers has also attracted widespread attention in recent years.This article reviews the application of nanocarrier-NIR PTT.

关 键 词：光热疗法 光热纳米载体 肿瘤靶向治疗 

分 类 号：R454.2[医药卫生—治疗学] R73[医药卫生—临床医学]