幼龄反刍动物瘤胃上皮细胞β-羟基丁酸代谢与调控机制  

Metabolism and Regulation Mechanism of Beta-hydroxybutyric Acid in Ruminal Epithelium Cells of Young Ruminants

作　　者：庄一民 刁其玉[1] 张乃锋[1] ZHUANG Yimin;DIAO Qiyu;ZHANG Naifeng(Key Laboratory of Feed Biotechnology of Ministry of Agriculture and Rural Affairs,Feed Research Institute of Chinese Academy of Agricultural Sciences,Beijing 100081,China)

机构地区：[1]中国农业科学院饲料研究所,农业农村部饲料生物技术重点开放实验室,北京100081

出　　处：《畜牧兽医学报》2020年第4期660-669,共10页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金(31872385);国家重点研发计划(2018YFD0501902)。

摘　　要：β-羟基丁酸(β-hydroxybutyric acid,BHBA)是酮体的主要成分之一,在反刍动物瘤胃中由微生物发酵产生的丁酸在瘤胃上皮细胞中氧化生成,BHBA对反刍动物瘤胃上皮细胞的代谢与增殖具有重要调控作用。近年来,有关BHBA研究多集中在肝脏生酮、奶牛酮病及泌乳等方面,关于BHBA与幼龄反刍动物瘤胃上皮细胞生长发育之间的关系及内在机制研究很少。本文重点针对BHBA在瘤胃上皮的生成、转运,以及BHBA作为信号分子调控瘤胃上皮细胞代谢与增殖的分子机制进行综述,这对于丰富瘤胃发育及调控理论与幼龄反刍动物培育营养策略具有重要意义。Beta-hydroxybutyric acid(BHBA)is one of the main components of ketones.BHBA is a metabolite of butyrate,which is produced by rumen microbial fermentation,in rumen epithelial cells.BHBA plays an important regulatory role in rumen epithelial cells proliferation and metabolism of ruminants.In recent years,most studies on BHBA have focused on liver ketogenesis,dairy cow ketosis and its effect on lactation.Little information is available in the literature regarding to the relationship and inherent mechanisms between BHBA and rumen epithelial cell growth in young ruminants.This review focuses on the formation and transport of BHBA in rumen epithelial cells,as well as the molecular mechanism of BHBA as a signal molecule regulating the metabolism and proliferation of rumen epithelial cells.This is of great significance to enrich the theory on regulation and development of rumen and the nutritional strategy for the rearing of young ruminants.

关 键 词：β-羟基丁酸 幼龄反刍动物 瘤胃上皮细胞 生酮作用 细胞增殖 

分 类 号：S811.6[农业科学—畜牧学]