异甘草酸镁与甘利欣治疗病毒性肝炎患者的临床效果比较  

Comparison of Clinical Effects between Magnesium Isoglycyrrhizinate and Glycyrrhizin in the Treatment of Patients with Viral Hepatitis

作　　者：韩瑞霞 HAN Rui-xia(Department of Infectious Diseases,Liangshan County People's Hospital,Jining,Shandong Province,272600 China)

机构地区：[1]山东省济宁市梁山县人民医院感染科,山东济宁272600

出　　处：《中外医疗》2020年第3期130-132,共3页China & Foreign Medical Treatment

摘　　要：目的比较异甘草酸镁与甘利欣治疗病毒性肝炎患者的临床效果。方法便利选择该院于2017年4月-2018年8月期间收治的病毒性肝炎患者92例,将患者进行随机分为研究组与对照组,每组46例。对照组给予甘利欣治疗,研究组给予异甘草酸镁治疗,比较两组总胆红素(TBIL)谷草转氨酶(AST)、谷丙转氨酶指标(ALT)、治疗有效率和不良反应发生率。结果治疗后研究组的TBIL、AST、ALT检测指标优于对照组(TBIL:t=4.189,P=0.000;AST:t=7.536,P=0.000;ALT:t=4.505,P=0.000),治疗有效率95.7%比对照组的82.6%高(χ~2=4.039,P=0.044),不良反应发生率2.2%比对照组的17.4%低(χ~2=4.929,P=0.026)。结论异甘草酸镁治疗病毒性肝炎的疗效更佳,推荐临床应用。Objective To compare the clinical effects of magnesium isoglycyrrhizinate and Ganlixin in the treatment of viral hepatitis. Methods Convenient selection ninety-two patients with viral hepatitis admitted to the hospital from April 2017 to August 2018 were randomLy divided into study group and control group, with 46 cases in each group. The control group was treated with glycyrrhizin. The study group was treated with magnesium isoglycyrrhizinate. The total bilirubin(TBIL) aspartate aminotransferase(AST), alanine aminotransferase(ALT), treatment efficiency and adverse reaction rate were compared between the two groups. Results After treatment, the TBIL, AST, and ALT test indexes of the study group were better than the control group(TBIL: t =4.189, P =0.000;AST: t =7.536, P =0.000;ALT: t =4.505, P =0.000). The efficiency was 95.7%higher than that of the control group(82.6%)(χ~2=4.039, P=0.044), and the incidence of adverse reactions was 2.2% lower than the control group’s 17.4%(χ~2=4.929, P=0.026).Conclusion Magnesium glycyrrhizinate is more effective in the treatment of viral hepatitis. It is recommended for clinical application.

关 键 词：异甘草酸镁 甘利欣 病毒性肝炎 临床效果 

分 类 号：R512[医药卫生—内科学]