针型化学传感器研制及其在体检测的应用及前景展望  

Development of Needle-type Chemical Sensor and Its Application and Prospect in Vivo Detection

作　　者：房钰鑫 郭义[2,3] 尹飞[2,4] 吴丽萍[2,4] 刘阳阳[1,2] 郭永明 苗文芳 陈进生[5] 徐汤苹 史丽英[2] 魏玉云 王雪争 马佳佳 FANG Yuxin;GUO Yi;YIN Fei;WU Liping;LIU Yangyang;GUO Yongming;MIAO Wenfang;CHEN Jinsheng;XU Tangping;SHI Liying;WEI Yuyun;WANG Xuezheng;MA Jiajia(College of Acumox and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Research Center of Experimental Acupuncture Science,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;College of Chinese Medical,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;College of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;College of Chemistry,Nankai University,Tianjin 300071,China)

机构地区：[1]天津中医药大学针灸推拿学院,天津301617 [2]天津中医药大学实验针灸学研究中心,天津301617 [3]天津中医药大学中医学院,天津301617 [4]天津中医药大学中药学院,天津301617 [5]南开大学化学学院,天津300071

出　　处：《世界中医药》2020年第7期983-989,共7页World Chinese Medicine

基　　金：国家自然科学基金面上项目(81973944);国家自然科学基金青年项目(81503636);天津市应用基础与前沿技术研究计划青年项目(15JCQNJC10800);天津市卫生和计划生育委员会中医中西医结合科研课题(2015071);天津市高等学校科技发展基金项目(2004Zd13);天津市教委科研课题(96507B)。

摘　　要：针型化学传感器是以针状物(针刺针、不锈钢针头、钨丝、针型塑料和铂丝等)为基体的一类检测仪器,能够实现生命体内某些特定化学物质的微创、在体和实时监测。本文结合团队国家中医药管理局科研三级实验室——医用化学传感器实验室多年的工作,参考国内针型化学传感器研究,对针型化学传感器检测钙离子、氢离子、氧分压、多巴胺、5-羟色胺、乙酰胆碱、去甲肾上腺素和腺苷等化学量的基本原理和研究、应用进展特别是在中医研究中的应用进行介绍,以期推动针型化学传感器的研究,为中医针灸研究提供技术支撑。Needle-type chemical sensor is a kind of detection instrument based on needle-like object(acupuncture needle,stainless steel needle,tungsten wire,needle plastic and platinum wire,etc.),which can realize the micro invasive in vivo and real-time monitoring of some specific biochemical substances in animals.Based on the work of iatrochemistry sensor laboratory,the third level scientific research laboratory of the National Administration of Traditional Chinese medicine,and referring to the research of needle sensor in China,this paper introduced the basic principals,research,application progress,especially the applicaton in TCM research of needle-type chemical sensor detecting calcium ion,hydrogen ion,oxygen partial pressure,dopamine,5-hydroxytryptamine,acetylcholine,noradrenaline and adenosine,in the hope of promoting the research of needle type chemical sensor and provide technical support for acupuncture research of traditional Chinese medicine.

关 键 词：化学传感器 离子型传感针 氧分压传感针 神经递质传感针 

分 类 号：R245-0[医药卫生—针灸推拿学]