醒脑开窍针刺法治疗血管性痴呆患者的疗效  

Effects in Patients with Vascular Dementia Using Acupuncture Method of Inducing Resuscitation

作　　者：叶海森[1] 武凯歌 张湘斌 陈曦[1] 周霞峰[1] 曹慧 YE Haisen;WU Kaige;ZHANG Xiangbin;CHEN Xi;ZHOU Xiafeng;CAO hui(Department of Psychiatry, Hunan Brain Hospital, Changsha 410007, Hunan,China;Department of Neurology, Hunan Brain Hospital, Changsha 410007, China)

机构地区：[1]湖南省脑科医院精神科,长沙410007 [2]湖南省脑科医院神经内科,长沙410007

出　　处：《世界中医药》2020年第7期1071-1074,共4页World Chinese Medicine

基　　金：湖南省自然科学基金项目(2019JJ8002680026)。

摘　　要：目的:探究醒脑开窍针刺法对血管性痴呆(VD)患者的简易智能状态量表(MMSE)评分、Barthel指数及基质金属蛋白酶(MMP)的影响。方法:选取2017年1月至2018年1月湖南省脑科医院收治的血管性痴呆患者共110例作为研究对象,随机分为观察组和对照组,每组55例。对照组采用常规针刺疗法;观察组采用醒脑开窍针刺疗法,2组疗程均为4周。比较2组患者治疗后治疗有效率及治疗前后MMSE、Barthel指数及MMP水平。结果:观察组、对照组的治疗有效率分别为92.72%和78.18%,差异有统计学意义(P<0.05);治疗后2组患者MMSE和Barthel指数均显著升高,差异有统计学意义(P<0.05),且观察组高于对照组,差异有统计学意义(P<0.05);治疗后2组患者的MMP-2和MMP-9值均下降,差异有统计学意义(P<0.05),且观察者组患者的MMP-2和MMP-9低于对照组,差异有统计学意义(P<0.05)。结论:醒脑开窍针刺法对VD患者疗效显著,能够有效缓解痴呆症状。Objective:To explore the effects on MMSE scores,Barthel indexes and matrix metalloproteinase(MMP)in patients with vascular dementia(VD)by using acupuncture method of inducing resuscitation.Methods:A total of 110 patients with VD in Hunan Brain Hospital were randomly divided into an observation group(55 cases)and a control group(55 cases).The control group was treated with routine acupuncture method while the observation group was treated with acupuncture method of inducing resuscitation.There were 2 weeks of treatment for the 2 groups.The total effective rates,MMSE scores,Barthel indexes and levels of MMP were compared between the 2 groups.Results:The total effective rates in the observation group and the control group were 92.72%and 78.18%,respectively,with significant difference(P<0.05).After treatment,the MMSE scores and Barthel indexes in the 2 groups increased significantly(P<0.05),and those in the observation group were higher than those in the control group,with significant difference(P<0.05).After treatment,the levels of MMP-2 and MMP-9 in the 2 groups decreased significantly(P<0.05);Moreover,those in the observation group were lower than those in the control group,with significant difference(P<0.05).Conclusion:Acupuncture method of inducing resuscitation is an effective therapy in treating VD patients and can effectively relieve the symptoms of dementia,which is worthy for further promotion and application.

关 键 词：醒脑开窍针 血管性痴呆 简易智能状态量表 基质金属蛋白酶 

分 类 号：R245[医药卫生—针灸推拿学] R543[医药卫生—中医临床基础]