水相中微波辅助合成喹唑啉-4(3H)-酮类衍生物的研究  

Microwave-assisted synthesis of quinazolin-4(3H)-ones in water

作　　者：李震 刘圣亚 李飞 孔迎春 LI Zhen;LIU Sheng-ya;LI Fei;KONG Ying-Chun(Office of Academic Research,Yunnan Normal University,Kunming 650500,China;Faculty of Graduate Studies,Assumption University,Bangkok 10240,Thailand)

机构地区：[1]云南师范大学科研处,云南昆明650500 [2]Faculty of Graduate Studies,Assumption University,Bangkok Thailand,10240

出　　处：《化学研究与应用》2020年第4期622-626,共5页Chemical Research and Application

基　　金：国家自然科学基金项目(21777136)资助;云南省教育厅科学研究基金项目(2015Y108)资助。

摘　　要：开展了2-卤代苯甲酰胺与腈类化合物反应生成喹唑啉-4(3H)-酮类衍生物的微波辅助合成研究。结果表明:在微波辅助条件下,生成的喹唑啉-4(3H)-酮类衍生物的速率均较常规加热条件下增大,并且2-碘代苯甲酰胺比2-溴苯甲酰胺活性更高。一系列的喹唑啉-4(3H)-酮衍生物被高效地合成出来,最高产率达到89%。Microwave-assisted organic synthesis of quinazolin-4(3H)-ones through the reaction of 2-halobenzamides and nitriles was investigated.The results showed the yield was improved significantly when the reaction was carried out under microwave irradiation.2-Iodobenzamides were more reactive than 2-bromobenzamides with higher yields.A variety of quinazolin-4(3H)-ones could be synthesized in good to excellent yields up to 89%.

关 键 词：微波辅助合成 喹唑啉-4(3H)-酮 2-卤代苯甲酰胺 腈类化合物 

分 类 号：O622.6[理学—有机化学]