卵巢摘除诱导围绝经期综合征动物模型的研究进展  

Research advances in animal models of perimenopausal syndrome induced by ovariectomy

作　　者：陶柱萍 韦桂宁[2] 王雪雪 厉颖 尹爱武 李灿委 范孟然 巫秀美 张成桂 高鹏飞 TAO Zhuping;WEI Guining;WANG Xuexue;LI Ying;YIN Aiwu;LI Canwei;FAN Mengran;WU Xiumei;ZHANG Chenggui;GAO Pengfei(School of Pharmacy,Dali University,Dali 671000,China;Department of Pharmaocology,Guangxi Institute of Chinese Medicine and Pharmaceutical Science,Nanning 530022;Xiangtan Medicine and Health Vocational College,Xiangtan 411102;College of Public Health,Dali University,Dali 671000;Yunnan Key Laboratory for Biomedical Research and Development of Insects,Dali University,Dali 671000;National Local Joint Engineering Research Center for the Development of Medicinal Special Insects,Dali 671000)

机构地区：[1]大理大学药学与化学学院,云南大理671000 [2]广西中医药研究院药理所,南宁530022 [3]湘潭医卫职业技术学院,湖南湘潭411102 [4]大理大学公共卫生学院,云南大理671000 [5]云南省昆虫生物医药研发重点实验室,云南大理671000 [6]药用特种昆虫开发国家地方联合工程研究中心,云南大理671000

出　　处：《中国实验动物学报》2020年第2期260-266,共7页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金资助项目(81260676,81960729,81560663,81703769);云南省地方本科高校(部分)基础研究联合专项项目(2018FH001-097);云南省教育厅科学研究基金重点项目(2013Z154);云南省2019年中药饮片产业发展专项资金(2019-YG-067)。

摘　　要：围绝经期综合征是由雌激素和孕酮等类固醇激素水平下降引起的一系列症状,严重影响女性的身心健康和生活质量,选择适当的动物模型研究该疾病显得尤为重要。卵巢摘除动物模型常用于围绝经期综合征的研究,包括骨质疏松、记忆下降和认知障碍、焦虑、抑郁、肥胖等。本文通过检索PubMed、中国知网(CNKI)数据库中卵巢摘除动物模型应用于围绝经期综合征的相关文献,对该动物模型应用于围绝经期综合征的研究进展进行了综述。Perimenopausal syndrome(PMS)is a series of symptoms caused by the decrease of steroid hormone levels,such as estrogen and progesterone,which seriously affect the physical and mental health and quality of life of women.To explore the etiology of the disease,it is important to select the right animal model.The ovariectomy animal model is often used in the study of PMS symptoms,such as osteoporosis,memory and cognitive impairment,anxiety,depression,and obesity.In this paper,research progress of the ovariectomy animal model applied to PMS is reviewed by searching the relevant literature of the ovariectomy animal model in PubMed and CNKI database for PMS.

关 键 词：围绝经期综合征 卵巢摘除 动物模型 

分 类 号：Q95-33[生物学—动物学]