奥沙利铂诱导的神经病理性疼痛大鼠模型研究及其在中医方面应用进展  

Rat model of neuropathic pain induced by oxaliplatin and its application in traditional Chinese medicine

作　　者：李明珠[1,2] 王文萍 金圣博[1,3] LI Mingzhu;WANG Wenping;JIN Shengbo(Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China;Cancer Hospital of China Medical University,Liaoning Cancer Hospital,Shenyang 110042;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032)

机构地区：[1]辽宁中医药大学,沈阳110032 [2]中国医科大学肿瘤医院,辽宁省肿瘤医院,沈阳110042 [3]辽宁中医药大学附属医院,沈阳110032

出　　处：《中国实验动物学报》2020年第2期278-285,共8页Acta Laboratorium Animalis Scientia Sinica

基　　金：“十三五”国家重点研发计划“重大慢性非传染性疾病防控研究”重点专项-“东北地区重大慢病防控科技综合示范研究”(2018YFC1311600);辽宁省“兴辽英才计划”(XLYC1802008)。

摘　　要：中医防治奥沙利铂化疗后诱导的神经病理性疼痛(chemotherapy-induced peripheral neuropathy,CIPN)有显著优势,但其应用方法和具体作用机制等仍待深入的研究和探索,因此需要更精准、更符合临床疾病发生发展规律的动物模型作为研究媒介。此文对近些年现有奥沙利铂所致的CIPN急性模型和慢性的建立和标准进行深入的探讨,及其在中医方面的应用做相关评价及阐述,以期能够为今后的研究提供参考。Chinese medicine has significant advantages in the prevention and treatment of chemotherapy-induced peripheral neuropathy(CIPN)induced by oxaliplatin.However,its application method and specific mechanisms need to be studied further.Therefore,a more precise understanding of the development of clinical diseases is required.Animal models are used as research vectors.This article provides an in-depth discussion on the establishment of acute and chronic models of CIPN induced by oxaliplatin in recent years,and their evaluation for the application of traditional Chinese medicine to provide reference for future research.

关 键 词：奥沙利铂 大鼠神经病理性疼痛模型 神经病理性疼痛 

分 类 号：Q95-33[生物学—动物学]