基于《社区获得性肺炎诊断和治疗指南(2016版)》对医院成人CAP患者抗菌药物使用的相关因素分析  

Analysis of Relevant Factor of Antibiotic Medication in Adult Patients with CAP in Hospital Based on "Guidelines of CAP 2016 Edition"

作　　者：曹季平[1] CAO Ji-ping(The No.1 People's Hospital o f Nantong,Nantong Jiangsu 226001,China)

机构地区：[1]南通市第一人民医院,江苏南通226001

出　　处：《抗感染药学》2020年第3期323-327,共5页Anti-infection Pharmacy

摘　　要：目的:分析医院成人社区获得性肺炎(CAP)住院患者的抗菌药物使用情况,为CAP的诊治和合理使用抗菌药物提供参考。方法:抽取2017年-2018年收治的CAP患者151例临床数据,依据《社区获得性肺炎的诊疗指南(2016版)》(以下简称《指南》)并结合患者临床症状,分析和衡量其使用抗菌药物的限定日剂量(DDD)和药物利用指数(DUI)合理性。结果:151例病例中,青壮年患者占比最大,且大多数病例伴随基础疾病,抗菌药物的使用率均为100%;所用抗菌药物以喹诺酮类和头孢菌素类酶抑制剂复合物为主,二联用药也常以上述两类药物联用;多数药物DUI值接近于1.00,用法用量较为合理;不良反应发生率低且多为常见反应。结论:医院CAP患者抗菌药物的使用基本符合《指南》要求,部分药物DUI值波动大,联合用药不合理的问题需引起临床重视。Objective: To analyze the usage of antimicrobial agents in hospital adult inpatients with community acquired pneumonia(CAP), and to provide a reference for the diagnosis, treatment and rational usage of antibiotics in CAP. Methods: Clinical data of 151 patients with CAP admitted from 2017 to 2018 were extracted. According to "The Guidelines for the Diagnosis and Treatment of Community Acquired Pneumonia(2016 edition)"(hereinafter referred to as the "Guidelines") and combined with the clinical symptoms of the patients, the rationality of the prescribed daily dose(DDD) and drug utilization index(DUI) for the use of antibiotics were analyzed and measured. Results: Among the151 cases of CAP, the young and middle-aged patients accounted for the largest proportion, and most of the cases were accompanied by basic diseases, and the utilization rate of antibacterial drugs was 100.00%. The main antibiotics used were quinolones and cephalosporin enzyme inhibitor complexes, and the combination of the two drugs is often used together. The DUI value of most drugs was close to 1.00, and the usage and dosage were reasonable. The incidence of adverse drug reactions was low and most of them were common. Conclusion: The usage of antibacterial drugs in hospital CAP patients basically conformed to the requirements of "The guidelines", and the DUI value of some drugs fluctuated greatly, so the unreasonable combination of drugs should be paid more attention in clinic.

关 键 词：社区获得性肺炎(CAP) 抗菌药物 药物利用指数(DUI) 合理用药 

分 类 号：R969.3[医药卫生—药理学]